Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,252 questions · 2,353 findings · 210 reviews · Neonatal

No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

nHFV vs nIPPV following failure of initial non‐invasive respiratory support

Mortality before hospital discharge · ventilated preterm infants with failure of initial non‐invasive respiratory support

nHFV showed no clear difference in mortality before hospital discharge compared with nIPPV following failure of initial non‐invasive respiratory support (low certainty).

1 finding from 1 review

nHFV vs nIPPV following failure of initial non‐invasive respiratory support

Endotracheal intubation To discharge · ventilated preterm infants with failure of initial non‐invasive respiratory support

It is very uncertain whether nHFV changes endotracheal intubation To discharge compared with nIPPV following failure of initial non‐invasive respiratory support (very low certainty).

1 finding from 1 review

nHFV vs nIPPV following failure of initial non‐invasive respiratory support

Chronic lung disease · ventilated preterm infants with failure of initial non‐invasive respiratory support

nHFV showed no clear difference in chronic lung disease compared with nIPPV following failure of initial non‐invasive respiratory support (low certainty).

1 finding from 1 review

nHFV vs nIPPV following failure of initial non‐invasive respiratory support

Intraventricular haemorrhage, Papile grade 3/4 · ventilated preterm infants with failure of initial non‐invasive respiratory support

nHFV showed no clear difference in intraventricular haemorrhage, Papile grade 3/4 compared with nIPPV following failure of initial non‐invasive respiratory support (low certainty).

1 finding from 1 review

Exposure vs no exposure to the smell and taste of milk with tube feeds

Necrotising Enterocolitis ≥ Bell's stage 2 during initial hospital stay · preterm infants

Exposure showed no clear difference in necrotising enterocolitis during hospitalisation (Bell's stage ≥ 2) compared with no exposure to the smell and taste of milk with tube feeds (low certainty).

1 finding from 1 review