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Evidence found and GRADE certainty

1,494 questions · 1,521 findings · 132 reviews · Hepato-Biliary

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No studies found 303 · 19.9%GRADE not reported 39 · 2.6%Very low 876 · 57.6%Low 216 · 14.2%Moderate 65 · 4.3%High 22 · 1.4%

Summary of findings table ‐ Endoscopic sphincterotomy vs sham

Proportion of participants with ≥ 1 serious adverse events at 1 year · adults with biliary sphincter of Oddi dysfunction

It is very uncertain whether summary of findings table ‐ Endoscopic sphincterotomy changes proportion of participants with ≥ 1 serious adverse events at 1 year compared with sham treatment (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Endoscopic sphincterotomy vs sham

Quality of life · adults with biliary sphincter of Oddi dysfunction
2 findings from 1 review

Summary of findings table ‐ Endoscopic sphincterotomy vs endoscopic papillary balloon dilation

Proportion of participants with ≥ 1 serious adverse events at 1 year · adults with biliary sphincter of Oddi dysfunction

It is very uncertain whether summary of findings table ‐ Endoscopic sphincterotomy changes proportion of participants with ≥ 1 serious adverse events at 1 year compared with endoscopic papillary balloon dilation (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

All‐cause mortality · farmworkers, soldiers, and people in endemic areas

Summary of findings table ‐ Antibiotics showed no clear difference in all‐cause mortality compared with placebo or no intervention (low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Clinical diagnosis of leptospirosis regardless of laboratory confirmation · farmworkers

It is very uncertain whether summary of findings table ‐ Antibiotics changes clinical diagnosis of leptospirosis regardless of laboratory… compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Laboratory‐confirmed leptospirosis · farmworkers

It is very uncertain whether summary of findings table ‐ Antibiotics changes clinical diagnosis of leptospirosis confirmed by laboratory diagnosis compared with other antibiotics (very low certainty).

2 findings from 1 review

Antibiotics vs other antibiotics

Non‐serious adverse events · farmworkers

It is very uncertain whether summary of findings table ‐ Antibiotics changes non‐serious adverse events compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Laboratory‐confirmed leptospirosis · farmworkers, soldiers, and people in endemic areas

It is very uncertain whether summary of findings table ‐ Antibiotics changes laboratory‐confirmed leptospirosis compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Clinical diagnosis of infection regardless of laboratory confirmed · farmworkers, soldiers, and people in endemic areas

Summary of findings table ‐ Antibiotics showed no clear difference in clinical diagnosis of infection regardless of laboratory confirmed compared with placebo or no intervention (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Clinical diagnosis confirmed by laboratory diagnosis · farmworkers, soldiers, and people in endemic areas

Summary of findings table ‐ Antibiotics showed no clear difference in clinical diagnosis confirmed by laboratory diagnosis compared with placebo or no intervention (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Non‐serious adverse events · farmworkers, soldiers, and people in endemic areas

It is very uncertain whether summary of findings table ‐ Antibiotics changes non‐serious adverse events compared with placebo or no intervention (very low certainty).

1 finding from 1 review