Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

959 questions · 987 findings · 78 reviews · Haematology

No studies found 256 · 25.9%GRADE not reported 64 · 6.5%Very low 207 · 21%Low 247 · 25%Moderate 163 · 16.5%High 50 · 5.1%

Intervention not reported

All cause mortality subgroup analysis age>60 · Prevention and treatment of infectious complications in patients with acute myelogenous leukemia

The intervention showed no clear difference in all cause mortality subgroup analysis age>60 (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality subgroup analysis age< 60 · Prevention and treatment of infectious complications in patients with acute myelogenous leukemia

The intervention showed no clear difference in all‐cause mortality subgroup analysis age< 60 (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality ‐ sensitivity analysis · Prevention and treatment of infectious complications in patients with acute myelogenous leukemia

The intervention showed no clear difference in all‐cause mortality ‐ sensitivity analysis (high certainty).

1 finding from 1 review

Cytarabine plus high‐dose methotrexate vs high‐dose methotrexate alone

Mortality Median · patients with primary CNS lymphoma

Cytarabine plus high‐dose methotrexate showed no clear difference in mortality (median 3 years) compared with high‐dose methotrexate alone (moderate certainty).

1 finding from 1 review

Cytarabine plus high‐dose methotrexate vs high‐dose methotrexate alone

Progression/relapse · patients with primary CNS lymphoma

Cytarabine plus high‐dose methotrexate probably leads to lower progression/relapse (median 3 years) compared with high‐dose methotrexate alone (moderate certainty).

1 finding from 1 review

Cytarabine plus high‐dose methotrexate vs high‐dose methotrexate alone

Treatment‐related mortality · patients with primary CNS lymphoma

Cytarabine plus high‐dose methotrexate showed no clear difference in treatment‐related mortality compared with high‐dose methotrexate alone (moderate certainty).

1 finding from 1 review

Cytarabine plus high‐dose methotrexate vs high‐dose methotrexate alone

Severe adverse effects (grade 3+): Infection · patients with primary CNS lymphoma

Cytarabine plus high‐dose methotrexate probably leads to higher infections (grade 3 to 4) compared with high‐dose methotrexate alone (moderate certainty).

1 finding from 1 review