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Evidence found and GRADE certainty

2,079 questions · 2,112 findings · 171 reviews · Eyes and Vision

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No studies found 587 · 27.8%GRADE not reported 95 · 4.5%Very low 446 · 21.1%Low 557 · 26.4%Moderate 361 · 17.1%High 66 · 3.1%

Extended‐fixed vs monthly injections

Proportion of participants with endophthalmitis · people with neovascular age‐related macular degeneration

Extended‐fixed showed no clear difference in endophthalmitis (ocular adverse event) compared with monthly injections (low certainty).

1 finding from 1 review

'As needed' administration (e.g. based on pain scales) vs monthly injections

Gain of 3 or more lines of visual acuity · people with neovascular age‐related macular degeneration

As needed may leads to lower gain of ≥ 15 letters visual acuity at 1 year compared with monthly injections (low certainty).

1 finding from 1 review

'As needed' administration (e.g. based on pain scales) vs monthly injections

Central retinal thickness μm (CRT) change at 1 year The aim of treatment is to reduce central retinal thickness so thinner is better. · people with neovascular age‐related macular degeneration
1 finding from 1 review

'As needed' administration (e.g. based on pain scales) vs monthly injections

Proportion of participants with endophthalmitis · people with neovascular age‐related macular degeneration

As needed probably leads to lower endophthalmitis (ocular adverse event) compared with monthly injections (moderate certainty).

1 finding from 1 review

Extended‐fixed vs monthly injections

Gain of 3 or more lines of visual acuity · people with neovascular age‐related macular degeneration

Extended‐fixed showed no clear difference in gain of ≥ 15 letters visual acuity at 1 year compared with monthly injections (moderate certainty).

1 finding from 1 review

Mitomycin C dacryocystorhinostomy vs dacryocystorhinostomy alone

Functional success, defined as the relief of epiphora · nasolacrimal duct obstruction

Mitomycin C dacryocystorhinostomy showed no clear difference in functional success, defined as the relief of epiphora compared with dacryocystorhinostomy alone (low certainty).

2 findings from 1 review

Mitomycin C dacryocystorhinostomy vs dacryocystorhinostomy alone

Anatomic success, defined as patency to lacrimal irrigation · nasolacrimal duct obstruction

Mitomycin C dacryocystorhinostomy showed no clear difference in anatomic success, defined as patency to lacrimal irrigation compared with dacryocystorhinostomy alone (low certainty).

2 findings from 1 review

Mitomycin C dacryocystorhinostomy vs dacryocystorhinostomy alone

Ostium size on nasal endoscopy · nasolacrimal duct obstruction

Mitomycin C dacryocystorhinostomy showed no clear difference in ostium size on nasal endoscopy compared with dacryocystorhinostomy alone (low certainty).

2 findings from 1 review

Wavefront procedures vs conventional procedures

Proportion of eyes with uncorrected visual acuity (UCVA) of 20/20 or better post‐treatment. ‐ 12 months · Adults with refractive errors

Wavefront procedures showed no clear difference in proportion of eyes with uncorrected visual acuity (UCVA) of 20/20 or… compared with conventional procedures (low certainty).

1 finding from 1 review

Wavefront‐optimized procedures vs wavefront‐guided procedures

Eyes within ± 0.5 D of target refraction · Adults with refractive errors

Wavefront‐optimized procedures showed no clear difference in proportion of eyes within ± 0.50 diopters (D) of target refraction… compared with wavefront‐guided procedures (low certainty).

1 finding from 1 review