Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,139 questions · 1,173 findings · 89 reviews · Neuromuscular

No studies found 302 · 25.7%GRADE not reported 119 · 10.1%Very low 267 · 22.8%Low 239 · 20.4%Moderate 177 · 15.1%High 69 · 5.9%

Electrical muscle stimulation vs control

Occurrence of CIP/CIM ‐ in the total population randomised · critically ill patients

It is very uncertain whether electrical muscle stimulation changes occurrence of CIP/CIM ‐ in the total population randomised compared with control (very low certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Occurrence of CIP/CIM ‐ in screened population · critically ill patients

Intensive insulin therapy probably leads to lower occurrence of CIP/CIM ‐ in screened population compared with conventional insulin therapy (moderate certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Death ‐ at 30 days after ICU admission, in total population randomised · critically ill patients

Intensive insulin therapy showed no clear difference in death ‐ at 30 days after ICU admission, in total population randomised compared with conventional insulin therapy (high certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Death ‐ at 180 days after ICU admission, in total population randomised · critically ill patients

Intensive insulin therapy showed no clear difference in death ‐ at 180 days after ICU admission, in total population… compared with conventional insulin therapy (moderate certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Serious adverse events, ‐ in total population randomised ‐ hypoglycaemia · critically ill patients

Intensive insulin therapy leads to higher serious adverse events, ‐ in total population randomised ‐… compared with conventional insulin therapy (high certainty).

1 finding from 1 review

Intervention not reported

Presence of PHN 6 months after the onset of the acute herpetic rash2 Clinical diagnostic criteria for PHN in any intensity · people with acute herpes zoster1
1 finding from 1 review

Intervention not reported

Presence of PHN 4 months after the onset of the acute herpetic rash Clinical diagnostic criteria for PHN in any intensity · people with acute herpes zoster1

The intervention showed no clear difference in presence of PHN 4 months after the onset of the acute herpetic rash… (high certainty).

1 finding from 1 review

Intervention not reported

Adverse events Clinical manifestations · people with acute herpes zoster1

The intervention showed no clear difference in adverse events Clinical manifestations (high certainty).

1 finding from 1 review

Intervention not reported

Number of patients with ≥ 50% improvement of pain at 12 weeks or less Duloxetine 60 mg daily 11‐point Likert score · patients with painful neuropathy or chronic pain from diabetic peripheral neuropathy

The intervention probably leads to higher number of patients with ≥ 50% improvement of pain at 12 weeks or… (moderate certainty).

1 finding from 1 review