Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,139 questions · 1,173 findings · 89 reviews · Neuromuscular

No studies found 302 · 25.7%GRADE not reported 119 · 10.1%Very low 267 · 22.8%Low 239 · 20.4%Moderate 177 · 15.1%High 69 · 5.9%

Nocturnal ventilation vs no ventilation

Unplanned admission to hospital · patients with neuromuscular and chest wall disorders and chronic hypoventilation

It is very uncertain whether nocturnal ventilation changes unplanned admission to hospital compared with no ventilation (very low certainty).

1 finding from 1 review

Nocturnal ventilation vs no ventilation

No improvement of hypoventilation symptoms: long‐term · patients with neuromuscular and chest wall disorders and chronic hypoventilation

It is very uncertain whether nocturnal ventilation changes no improvement of hypoventilation symptoms: long‐term compared with no ventilation (very low certainty).

1 finding from 1 review

Nocturnal ventilation vs no ventilation

No improvement of daytime hypercapnia: long‐term · patients with neuromuscular and chest wall disorders and chronic hypoventilation

It is very uncertain whether nocturnal ventilation changes no improvement of daytime hypercapnia: long‐term compared with no ventilation (very low certainty).

1 finding from 1 review

Volume‐cycled ventilation vs pressure‐cycled ventilation

Mortality at 1 year (or more) Not measured ‐ data reported for mortality at 3 months · patients with neuromuscular and chest wall disorders and chronic hypoventilation

It is very uncertain whether volume‐cycled ventilation changes mortality at 1 year (or more) Not measured ‐ data reported for… compared with pressure‐cycled ventilation (very low certainty).

1 finding from 1 review

Volume‐cycled ventilation vs pressure‐cycled ventilation

No improvement of hypoventilation symptoms: long‐term ‐ not measured · patients with neuromuscular and chest wall disorders and chronic hypoventilation

The review found no eligible studies for this question.

1 finding from 1 review

Volume‐cycled ventilation vs pressure‐cycled ventilation

No improvement of daytime hypercapnia: long‐term ‐ not measured · patients with neuromuscular and chest wall disorders and chronic hypoventilation

The review found no eligible studies for this question.

1 finding from 1 review

IVIg vs PE

Number improved by 1 or more disability grades after 4 weeks · patients with Guillain‐Barré syndrome

IVIg showed no clear difference in number improved by 1 or more disability grades after 4 weeks compared with PE (moderate certainty).

1 finding from 1 review

IVIg vs PE

Dead or disabled after 12 months (48 weeks) · patients with Guillain‐Barré syndrome

IVIg showed no clear difference in dead or disabled after 12 months (48 weeks) compared with PE (low certainty).

1 finding from 1 review

IVIg vs PE

Relapse or treatment‐related fluctuation · patients with Guillain‐Barré syndrome

IVIg showed no clear difference in relapse or treatment‐related fluctuation compared with PE (low certainty).

1 finding from 1 review

IVIg vs PE

Patients in whom treatment was discontinued · patients with Guillain‐Barré syndrome

IVIg leads to lower participants in whom treatment was discontinued compared with PE (high certainty).

1 finding from 1 review

IVIg vs PE

Number of patients with adverse events attributed to treatment · patients with Guillain‐Barré syndrome

IVIg showed no clear difference in number of participants with adverse events attributed to treatment compared with PE (moderate certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Occurrence of CIP/CIM ‐ in the total population randomised · critically ill patients

Intensive insulin therapy may leads to lower occurrence of CIP/CIM ‐ in total population randomised compared with conventional insulin therapy (low certainty).

1 finding from 1 review

Corticosteroids vs placebo compared

Serious adverse events (dichotomous data) ‐ suspected or probable pneumonia · critically ill patients

Corticosteroids showed no clear difference in serious adverse events (dichotomous data) ‐ suspected or probable… compared with placebo compared (high certainty).

1 finding from 1 review