Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

996 questions · 1,049 findings · 79 reviews · Dementia and Cognitive Improvement

No studies found 240 · 22.9%GRADE not reported 31 · 3%Very low 216 · 20.6%Low 253 · 24.1%Moderate 238 · 22.7%High 71 · 6.8%

Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo

Progression to Alzheimer's disease Number of people progressing to AD · MCI

Vitamin E (capsules 2000 IU/day in two divided doses) showed no clear difference in progression to Alzheimer's disease Number of people progressing to AD compared with placebo (moderate certainty).

1 finding from 1 review

Intensive glycaemic control vs conventional glucose control

All‐cause mortality · patients with type 2 diabetes mellitus

Intensive glycaemic control showed no clear difference in mortality compared with standard glycaemic control (moderate certainty).

1 finding from 1 review · compare the 2 reviews

Intensive glycaemic control vs conventional glucose control

Global cognitive function (defined as reduction of at least 3 points in MMSE) · patients with type 2 diabetes mellitus

Intensive glycaemic control showed no clear difference in global cognitive function (defined as reduction of at least 3 points… compared with standard glycaemic control (moderate certainty).

1 finding from 1 review