Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,811 questions · 70,850 findings · 5,139 reviews

No studies found 15,174 · 21.4%GRADE not reported 6,479 · 9.1%Very low 17,330 · 24.5%Low 17,814 · 25.1%Moderate 11,056 · 15.6%High 2,997 · 4.2%

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Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with the intent to rapidly extubate (InSurE)

Bronchopulmonary dysplasia · preterm infants with or at risk of respiratory distress syndrome

Surfactant administration via laryngeal mask airway (S‐LMA) showed no clear difference in bronchopulmonary dysplasia (clinical definition) among survivors compared with surfactant administration via endotracheal tube (ETT) with the… (low certainty).

1 finding from 1 review

Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with the intent to rapidly extubate (InSurE)

Intraventricular haemorrhage, Papile grade 3/4 · preterm infants with or at risk of respiratory distress syndrome
1 finding from 1 review

Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with the intent to rapidly extubate (InSurE)

Mortality before hospital discharge · preterm infants with or at risk of respiratory distress syndrome

Surfactant administration via laryngeal mask airway (S‐LMA) showed no clear difference in death (all causes) during the first hospitalisation Anytime to… compared with surfactant administration via endotracheal tube (ETT) with the… (low certainty).

1 finding from 1 review

Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with the intent to rapidly extubate (InSurE)

Neurosensory disability in survivors · preterm infants with or at risk of respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration through an endotracheal tube (S‐ETT)

Death or bronchopulmonary dysplasia · preterm infants with or at risk of respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration through an endotracheal tube (S‐ETT)

Need for mechanical ventilation · preterm infants with or at risk of respiratory distress syndrome

Surfactant administration via laryngeal mask airway (S‐LMA) may leads to lower mechanical ventilation at any time Any time to discharge compared with surfactant administration via endotracheal tube (ETT) with… (low certainty).

1 finding from 1 review

Summary of findings table ‐ Kappa‐opioid agonists vs placebo

Risk for at least one adverse drug reaction (ADR) per participant · patients with chronic kidney disease (CKD) pruritus

Summary of findings table ‐ Kappa‐opioid agonists may leads to higher risk for at least one adverse drug reaction (ADR) per patient compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ondansetron vs placebo

Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus

It is very uncertain whether summary of findings table ‐ Ondansetron changes risk for at least one adverse event per patient compared with placebo (very low certainty).

1 finding from 1 review