Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,495 questions · 1,554 findings · 140 reviews · Heart

No studies found 272 · 17.5%GRADE not reported 44 · 2.8%Very low 329 · 21.2%Low 464 · 29.9%Moderate 319 · 20.5%High 126 · 8.1%

Beta‐blockers vs placebo or no intervention

Myocardial infarction · patients with suspected or diagnosed myocardial infarction

Beta‐blockers showed no clear difference in myocardial infarction at maximum compared with placebo or no intervention (low certainty).

2 findings from 1 review

PAP therapy vs usual care

QoL · heart failure associated with central sleep apnoea
2 findings from 1 review

Natriuretic peptide‐guided treatment vs usual care

Cardiovascular hospitalisation (as defined by trialists) · patients without heart failure

Natriuretic peptide‐guided treatment probably leads to lower cardiovascular hospitalisation (as defined by trialists) compared with standard care (moderate certainty).

1 finding from 1 review

Natriuretic peptide‐guided treatment vs usual care

Hospitalisation (any cause) · patients without heart failure

Natriuretic peptide‐guided treatment probably leads to lower all‐cause hospitalisation (all occurrences) compared with standard care (moderate certainty).

1 finding from 1 review

Natriuretic peptide‐guided treatment vs usual care

Ventricular dysfunction (as defined by trialists) · patients without heart failure

Natriuretic peptide‐guided treatment leads to lower ventricular dysfunction (as defined by trialists) compared with standard care (high certainty).

1 finding from 1 review