Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,923 questions · 1,956 findings · 143 reviews · Musculoskeletal

No studies found 555 · 28.4%GRADE not reported 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Bisphosphonates vs placebo

Number of participants with change in bone pain (disappearance of pain)¹assessed on VAS · Paget's disease of bone

Bisphosphonates probably leads to higher number of participants with change in bone pain (disappearance of… compared with placebo (moderate certainty).

1 finding from 1 review

Zoledronate vs pamidronate or risedronate

Number of participants who experienced side effects related to use of bisphosphonates · Paget's disease of bone

Zoledronate showed no clear difference in number of participants who experienced side effects related to use… compared with pamidronate or risedronate (low certainty).

1 finding from 1 review

Bisphosphonates vs placebo

Number of participants who experienced radiologically‐confirmed fractures · Paget's disease of bone

It is very uncertain whether bisphosphonates changes number of participants who experienced radiologically‐confirmed… compared with placebo (very low certainty).

1 finding from 1 review

Bisphosphonates vs placebo

Number of participants who experienced side effects related to use of bisphosphonates · Paget's disease of bone

Bisphosphonates showed no clear difference in number of participants who experienced side effects related to use… compared with placebo (low certainty).

1 finding from 1 review

Bisphosphonates vs placebo

Withdrawals due to adverse events · Paget's disease of bone

Bisphosphonates showed no clear difference in number of participants who withdrew due to adverse events compared with placebo (low certainty).

1 finding from 1 review