Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,079 questions · 2,112 findings · 171 reviews · Eyes and Vision

No studies found 587 · 27.8%GRADE not reported 95 · 4.5%Very low 446 · 21.1%Low 557 · 26.4%Moderate 361 · 17.1%High 66 · 3.1%

Summary of Findings Table ‐ Large retro‐equatorial recession of horizontal rectus muscle of 9 mm on the medial rectus and 12 mm on the lateral rectus vs simple tenotomy and resuturing of the 4 horizontal rectus muscles

Change in head posture ‐ not reported · infantile nystagmus syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Summary of Findings Table ‐ Large retro‐equatorial recession of horizontal rectus muscle of 9 mm on the medial rectus and 12 mm on the lateral rectus vs simple tenotomy and resuturing of the 4 horizontal rectus muscles

Change in foveation period durations of the waveform ‐ not reported · infantile nystagmus syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Summary of Findings Table ‐ Large retro‐equatorial recession of horizontal rectus muscle of 9 mm on the medial rectus and 12 mm on the lateral rectus vs simple tenotomy and resuturing of the 4 horizontal rectus muscles

Change in visual recognition times ‐ not reported · infantile nystagmus syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Summary of Findings Table ‐ Large retro‐equatorial recession of horizontal rectus muscle of 9 mm on the medial rectus and 12 mm on the lateral rectus vs simple tenotomy and resuturing of the 4 horizontal rectus muscles

Change in proportion of participants with adverse effects with a probable causal link to the treatment · infantile nystagmus syndrome
1 finding from 1 review

Transepithelial CXL using iontophoresis vs epithelium‐off CXL

Proportion of participants whose maximum K decreased by at least 2 diopters—at 24 months · participants with progressive keratoconus

It is very uncertain whether transepithelial CXL using iontophoresis changes proportion of participants whose maximum K decreased by at least 2… compared with epithelium‐off CXL (very low certainty).

1 finding from 1 review

Transepithelial CXL using iontophoresis vs epithelium‐off CXL

Proportion of participants whose maximum K increased by at least 2 diopters—at 24 months · participants with progressive keratoconus

It is very uncertain whether transepithelial CXL using iontophoresis changes proportion of participants whose maximum K increased by at least 2… compared with epithelium‐off CXL (very low certainty).

1 finding from 1 review

Transepithelial CXL using iontophoresis vs epithelium‐off CXL

Proportion of participants whose keratoconus remained stable—at 24 months · participants with progressive keratoconus

It is very uncertain whether transepithelial CXL using iontophoresis changes proportion of participants whose keratoconus remained stable—at 24… compared with epithelium‐off CXL (very low certainty).

1 finding from 1 review

Transepithelial CXL using iontophoresis vs epithelium‐off CXL

Proportion of participants who gained 10 or more logMAR letters from baseline · participants with progressive keratoconus

It is very uncertain whether transepithelial CXL using iontophoresis changes proportion of participants who gained 10 or more logMAR letters from… compared with epithelium‐off CXL (very low certainty).

1 finding from 1 review

Transepithelial CXL using iontophoresis vs epithelium‐off CXL

Proportion of participants who lost 10 or more logMAR letters from baseline · participants with progressive keratoconus

It is very uncertain whether transepithelial CXL using iontophoresis changes proportion of participants who lost 10 or more logMAR letters from… compared with epithelium‐off CXL (very low certainty).

1 finding from 1 review

Transepithelial CXL vs epithelium‐off CXL

Proportion of participants whose maximum K decreased by at least 2 diopters—at 12 months · participants with keratoconus

It is very uncertain whether transepithelial CXL changes proportion of participants whose maximum K decreased by at least 2… compared with epithelium‐off CXL (very low certainty).

1 finding from 1 review

Transepithelial CXL vs epithelium‐off CXL

Proportion of participants whose maximum K increased by at least 2 diopters—at 12 months · participants with keratoconus

It is very uncertain whether transepithelial CXL changes proportion of participants whose maximum K increased by at least 2… compared with epithelium‐off CXL (very low certainty).

1 finding from 1 review