Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,497 questions · 1,590 findings · 129 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 281 · 17.7%GRADE not reported 74 · 4.7%Very low 410 · 25.8%Low 420 · 26.4%Moderate 280 · 17.6%High 125 · 7.9%

Intervention not reported

Intervention: radiotherapy Comparison: no adjuvant treatment Outcome: neurocognitive impairment at 5‐ to 6‐year · people with glioma surviving at least two years

It is very uncertain whether the intervention changes intervention: radiotherapy Comparison: no adjuvant treatment… (very low certainty).

1 finding from 1 review

Intervention not reported

Intervention: radiotherapy Comparison: no adjuvant treatment Outcome: neurocognitive impairment at 12 year · people with glioma surviving at least two years

It is very uncertain whether the intervention changes intervention: radiotherapy Comparison: no adjuvant treatment… (very low certainty).

1 finding from 1 review

Intervention not reported

Intervention: radiotherapy Comparison: no adjuvant treatment Outcome: neurocognitive impairment at 2 year · people with glioma surviving at least two years

It is very uncertain whether the intervention changes intervention: radiotherapy Comparison: no adjuvant treatment… (very low certainty).

1 finding from 1 review

Intervention not reported

Intervention: radiotherapy Comparison: chemotherapy Outcome: neurocognitive impairment at 3 year · people with glioma surviving at least two years

The intervention showed no clear difference in intervention: radiotherapy Comparison: chemotherapy Outcome:… (low certainty).

1 finding from 1 review

Intervention not reported

Intervention: high‐dose radiotherapy Comparison: low‐dose radiotherapy Outcome: neurocognitive impairment at 2 years after treatment · people with glioma surviving at least two years

It is very uncertain whether the intervention changes intervention: high‐dose radiotherapy Comparison: low‐dose… (very low certainty).

1 finding from 1 review

Intervention not reported

Intervention: high‐dose radiotherapy Comparison: low‐dose radiotherapy Outcome: neurocognitive impairment at 5 years after treatment · people with glioma surviving at least two years

It is very uncertain whether the intervention changes intervention: high‐dose radiotherapy Comparison: low‐dose… (very low certainty).

1 finding from 1 review

Intervention not reported

Intervention: chemoradiotherapy Comparison: radiotherapy Outcome: neurocognitive impairment at 3 years after treatment · people with glioma surviving at least two years

The intervention showed no clear difference in intervention: chemoradiotherapy Comparison: radiotherapy Outcome:… (low certainty).

1 finding from 1 review

Intervention not reported

Intervention: stereotactic conformal radiotherapy Comparison: radiotherapy Outcome: neurocognitive impairment at 5 years after treatment · people with glioma surviving at least two years

The intervention showed no clear difference in intervention: stereotactic conformal radiotherapy Comparison:… (low certainty).

1 finding from 1 review

Intervention not reported

Overall survival (deaths at 1 year) · adults with glioblastoma

It is very uncertain whether the intervention changes overall survival (deaths at 1 year) (very low certainty).

1 finding from 1 review

Intervention not reported

Overall survival (deaths at 2 years) · adults with glioblastoma

It is very uncertain whether the intervention changes overall survival (deaths at 2 years) (very low certainty).

1 finding from 1 review