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What do systematic reviews say?

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Evidence found and GRADE certainty

1,923 questions · 1,956 findings · 143 reviews · Musculoskeletal

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No studies found 555 · 28.4%GRADE not reported 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Paracetamol vs placebo

Liver toxicity: number experiencing abnormal liver function tests 24 weeks · Patients with osteoarthritis of the knee or hip

Paracetamol probably leads to higher liver toxicity: number experiencing abnormal liver function tests 24… compared with placebo (moderate certainty).

1 finding from 1 review

Paracetamol vs placebo

Serious adverse events: number experiencing 24 weeks · Patients with osteoarthritis of the knee or hip

Paracetamol showed no clear difference in serious adverse events: number experiencing 24 weeks compared with placebo (moderate certainty).

1 finding from 1 review

MX exercise training vs control

Withdrawal (all‐cause) · patients with fibromyalgia

MX exercise training showed no clear difference in all‐cause withdrawal All‐cause withdrawals from studies Median… compared with control (moderate certainty).

1 finding from 1 review

Surgery vs non‐surgical treatment

Global assessment of treatment success · people with full‐thickness rotator cuff tears

Surgery showed no clear difference in participant‐rated global assessment of treatment success at 12 months compared with non‐operative treatment (low certainty).

1 finding from 1 review