Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,497 questions · 1,590 findings · 129 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 281 · 17.7%GRADE not reported 74 · 4.7%Very low 410 · 25.8%Low 420 · 26.4%Moderate 280 · 17.6%High 125 · 7.9%

GnRH agonist plus chemotherapy vs chemotherapy alone

Menstruation recovery or maintenance: · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

GnRH agonist plus chemotherapy may leads to higher menstruation recovery or maintenance: compared with chemotherapy alone (low certainty).

2 findings from 1 review

GnRH agonist‐antagonist cotreatment plus chemotherapy vs chemotherapy alone

Pregnancy · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

It is very uncertain whether gnRH agonist‐antagonist cotreatment plus chemotherapy changes pregnancy compared with chemotherapy alone (very low certainty).

1 finding from 1 review

GnRH agonist plus chemotherapy vs chemotherapy alone

Premature ovarian failure · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

GnRH agonist plus chemotherapy probably leads to lower premature ovarian failure compared with chemotherapy alone (moderate certainty).

1 finding from 1 review

GnRH agonist plus chemotherapy vs chemotherapy alone

Pregnancy · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

GnRH agonist plus chemotherapy showed no clear difference in pregnancy compared with chemotherapy alone (low certainty).

1 finding from 1 review

GnRH agonist plus chemotherapy vs chemotherapy alone

Ovulation · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

GnRH agonist plus chemotherapy may leads to higher ovulation compared with chemotherapy alone (low certainty).

1 finding from 1 review

GnRH agonist plus chemotherapy vs chemotherapy alone

Adverse effects: hot flush · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

It is very uncertain whether gnRH agonist plus chemotherapy changes adverse effects: hot flush compared with chemotherapy alone (very low certainty).

1 finding from 1 review

GnRH agonist plus chemotherapy vs chemotherapy alone

Adverse effects: vaginal dryness · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

GnRH agonist plus chemotherapy showed no clear difference in adverse effects: vaginal dryness compared with chemotherapy alone (moderate certainty).

1 finding from 1 review

GnRH agonist‐antagonist cotreatment plus chemotherapy vs chemotherapy alone

Menstruation recovery or maintenance: · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

It is very uncertain whether gnRH agonist‐antagonist cotreatment plus chemotherapy changes menstruation recovery or maintenance: compared with chemotherapy alone (very low certainty).

2 findings from 1 review

Ovarian stimulating drugs in subfertile women vs subfertile women not treated or versus general population

Risk of invasive ovarian cancer in subfertile women exposed to ovarian stimulating drug vs unexposed women (summary of cohort studies suggesting increased risk) · subfertile women
2 findings from 1 review

Ovarian stimulating drugs in subfertile women vs subfertile women not treated or versus general population

Risk of borderline ovarian cancer in subfertile women exposed to ovarian stimulating drugs vs unexposed women (summary of case‐control studies suggesting an increase) · subfertile women
2 findings from 1 review