PUFA vs placebo
- Polyunsaturated fatty acids (PUFA) for attention deficit hyperactivity disorder (ADHD) in children and adolescents 2023 · Cochrane Headline outcomes onlyno estimate extracted12 studies · 960 participantsHigh
Summary of findings table ‐ PUFA showed no clear difference in side effects – overall compared with placebo (moderate certainty).
Summary of findings table ‐ PUFA showed no clear difference in loss to compared with placebo (moderate certainty).
Zinc supplementation showed no clear difference in all‐cause mortality compared with no zinc supplementation (high certainty).
Zinc supplementation showed no clear difference in mortality due to all‐cause diarrhea compared with no zinc supplementation (moderate certainty).
Zinc supplementation showed no clear difference in mortality due to LRTI compared with no zinc supplementation (moderate certainty).
Zinc supplementation showed no clear difference in mortality due to malaria compared with no zinc supplementation (moderate certainty).
Zinc supplementation probably leads to lower incidence of all‐cause diarrhea compared with no zinc supplementation (moderate certainty).
Zinc supplementation showed no clear difference in incidence of LRTI compared with no zinc supplementation (high certainty).
Zinc supplementation leads to higher participants with ≥ 1 vomiting episode compared with no zinc supplementation (high certainty).
It is very uncertain whether methylphenidate changes ADHD symptoms: all parallel‐group trials and first‐period cross‐over… compared with placebo or no intervention (very low certainty).
It is very uncertain whether methylphenidate changes proportion of participants with one or more serious adverse events compared with placebo or no intervention (very low certainty).
It is very uncertain whether methylphenidate changes proportion of participants with one or more adverse events… compared with placebo or no intervention (very low certainty).
It is very uncertain whether methylphenidate changes general behaviour: all parallel‐group trials and first‐period… compared with placebo or no intervention (very low certainty).
It is very uncertain whether methylphenidate changes quality of life (parent‐rated) compared with placebo or no intervention (very low certainty).
The review found no eligible studies for this question.