Cochrane · systematic review · CD007986
Polyunsaturated fatty acids (PUFA) for attention deficit hyperactivity disorder (ADHD) in children and adolescents
Gillies, D, Leach, MJ, Perez Algorta, G · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Developmental, Psychosocial and Learning ProblemsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 16.7%Moderate 2 · 33.3%High 3 · 50%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ PUFA compared to placebo for children and adolescents with ADHD
Population: children and adolescents with ADHD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
ADHD symptoms – improvement – medium term Summary of findings table ‐ PUFA vs placebo | RR 1.95 [1.47, 2.6] | 3 studies · 191 participants | Low Downgraded: risk of bias, imprecision |
ADHD symptoms – total, parent‐rated – medium term Summary of findings table ‐ PUFA vs placebo | no estimate extracted | 16 studies · 1166 participants | High |
ADHD symptoms – inattention, parent‐rated – medium term Summary of findings table ‐ PUFA vs placebo | no estimate extracted | 12 studies · 960 participants | High |
ADHD symptoms – hyperactivity/impulsivity, parent‐rated – medium term Summary of findings table ‐ PUFA vs placebo | no estimate extracted | 10 studies · 869 participants | High |
Side effects – overall Summary of findings table ‐ PUFA vs placebo | RR 1.02 [0.69, 1.52] | 8 studies · 591 participants | Moderate Downgraded: imprecision |
Loss to Summary of findings table ‐ PUFA vs placebo | RR 1.03 [0.77, 1.37] | 13 studies · 1121 participants | Moderate Downgraded: imprecision |