Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,495 questions · 1,554 findings · 140 reviews · Heart

No studies found 272 · 17.5%GRADE not reported 44 · 2.8%Very low 329 · 21.2%Low 464 · 29.9%Moderate 319 · 20.5%High 126 · 8.1%

Benznidazole vs placebo

Clearance of parasitaemia demonstrated by negative xenodiagnosis, blood culture, and/or molecular assays (N) · adults with both late‐stage, symptomatic Chagas disease and CCC

It is very uncertain whether benznidazole changes clearance of parasitaemia demonstrated by negative xenodiagnosis,… compared with placebo (very low certainty).

1 finding from 1 review

Benznidazole vs placebo

Clinical improvement (N) (a) Heart failure (b) Sustained ventricular tachycardia · adults with both late‐stage, symptomatic Chagas disease and CCC

Benznidazole showed no clear difference in clinical improvement (N) (a) Heart failure (b) Sustained ventricular… compared with placebo (low certainty).

1 finding from 1 review

IVIg vs placebo or no treatment

Event‐free survival (no death, transplant, or left ventricular assist device) ‐ adults with myocarditis · adults with acute myocarditis

It is very uncertain whether intravenous immunoglobulin changes event‐free survival (risk of death, cardiac transplant, or left… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

IVIg vs placebo or no treatment

Overall survival (risk of death) ‐ adults with myocarditis, median · adults with acute myocarditis

It is very uncertain whether intravenous immunoglobulin changes overall survival (risk of death) ‐ adults with myocarditis, median compared with placebo or no treatment (very low certainty).

1 finding from 1 review

IVIg vs placebo or no treatment

Overall survival (risk of death) ‐ children with myocarditis, 6‐month · children with acute myocarditis

It is very uncertain whether intravenous immunoglobulin changes overall survival (risk of death) ‐ children with myocarditis, 6‐month compared with placebo or no treatment (very low certainty).

1 finding from 1 review