Findings

What do systematic reviews say?

996 questions · 1,049 findings · 79 reviews · Dementia and Cognitive Improvement

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No studies found 240 · 22.9%GRADE not reported 31 · 3%Very low 216 · 20.6%Low 253 · 24.1%Moderate 238 · 22.7%High 71 · 6.8%

Benzodiazepines (lorazepam) vs placebo

Mortality from all causes · end‐of‐life patients with advanced cancer and an episode of agitated delirium

Benzodiazepines (lorazepam) showed no clear difference in mortality from all causes compared with placebo (low certainty).

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
RR 0.33 [0.04, 3.02]
1 study · 58 participants
Low

Benzodiazepines (lorazepam) vs chlorpromazine

Length of delirium episode · adult AIDS patients with delirium

The review found no eligible studies for this question.

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzodiazepines (lorazepam) vs chlorpromazine

Severity of delirium · adult AIDS patients with delirium

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Very low

Benzodiazepines (lorazepam) vs chlorpromazine

Any adverse event ESRS, higher = worse · adult AIDS patients with delirium

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Very low

Benzodiazepines (lorazepam) vs chlorpromazine

Duration of hospital admission (days) · adult AIDS patients with delirium

The review found no eligible studies for this question.

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Clinical Global (CIBIC+) · Alzheimer's disease (AD), moderate‐to‐severe

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 2797 participants
High

Intervention not reported

Clinical Global: (CIBIC+) · vascular dementia, mild‐to‐moderate severity

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 757 participants
Moderate

Intervention not reported

Cognitive function: ADAS‐Cog 70‐point scale · vascular dementia, mild‐to‐moderate severity

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 569 participants
Moderate

Intervention not reported

Performance on ADL (NOSGER self care subscale) Subscale 5 points · vascular dementia, mild‐to‐moderate severity

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 542 participants
Low

Intervention not reported

Behaviour: NOSGER disturbing behaviour subscale Subscale 5 points · vascular dementia, mild‐to‐moderate severity

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 542 participants
Low

Intervention not reported

Binary outcomes · vascular dementia, mild‐to‐moderate severity

The review found no eligible studies for this question.

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

All‐cause discontinuation · vascular dementia, mild‐to‐moderate severity

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 900 participants
Low

Intervention not reported

Number suffering at least one adverse event · vascular dementia, mild‐to‐moderate severity

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
29 studies · 8033 participants
High

Intervention not reported

Number suffering at least one serious adverse event · vascular dementia, mild‐to‐moderate severity

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 900 participants
Low

Intervention not reported

Number suffering agitation as an adverse event · vascular dementia, mild‐to‐moderate severity

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 900 participants
Low

Intervention not reported

Cognitive Function (SIB) · Alzheimer's disease (AD), moderate‐to‐severe

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 3337 participants
High

Intervention not reported

Functional performance on activities of daily living: ADCS‐ADL19 54‐point scale · Alzheimer's disease (AD), moderate‐to‐severe

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 2687 participants
High

Intervention not reported

Behaviour and Mood (NPI) · Alzheimer's disease (AD), moderate‐to‐severe

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
14 studies · 3674 participants
High

Intervention not reported

Binary outcomes · Alzheimer's disease (AD), moderate‐to‐severe

The review found no eligible studies for this question.

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

All‐cause discontinuation · Alzheimer's disease (AD), moderate‐to‐severe

1 finding from 1 review

Memantine for dementia 2019 · Cochrane Headline outcomes only
no estimate extracted
17 studies · 5087 participants
High