Peak withdrawal score · People undergoing managed opioid withdrawal
1 finding from 1 review
Overall withdrawal severity · People undergoing managed opioid withdrawal
1 finding from 1 review
Duration of treatment · People undergoing managed opioid withdrawal
1 finding from 1 review
Number experiencing hypotensive or other adverse effects · People undergoing managed opioid withdrawal
Alpha2‐adrenergic agonist may leads to higher number experiencing hypotensive or other adverse effects compared with methadone (low certainty).
1 finding from 1 review
Adverse effects (drop‐outs due to adverse effects4) · People undergoing managed opioid withdrawal
Alpha2‐adrenergic agonist showed no clear difference in drop‐out due to adverse effects compared with methadone (low certainty).
1 finding from 1 review
Completion of treatment · People undergoing managed opioid withdrawal
Alpha2‐adrenergic agonist showed no clear difference in completion of treatment compared with methadone (low certainty).
1 finding from 1 review
Participants with severe withdrawal · People undergoing managed opioid withdrawal
Alpha2‐adrenergic agonist probably leads to lower participants with severe withdrawal compared with placebo (moderate certainty).
1 finding from 1 review
Completion of treatment · People undergoing managed opioid withdrawal
Alpha2‐adrenergic agonist probably leads to higher completion of treatment compared with placebo (moderate certainty).
1 finding from 1 review
Intervention not reported
Cannabis use frequency at short‐term · adults with cannabis use disorder or frequent cannabis use
The intervention probably leads to higher cannabis use frequency at short‐term (moderate certainty).
1 finding from 1 review
Intervention not reported
Point‐prevalence abstinence rates at short‐term · adults with cannabis use disorder or frequent cannabis use
The intervention may leads to higher point‐prevalence abstinence rates at short‐term (low certainty).
1 finding from 1 review
Intervention not reported
Cannabis use quantity per day at short‐term · adults with cannabis use disorder or frequent cannabis use
It is very uncertain whether the intervention changes cannabis use quantity per day at short‐term (very low certainty).
1 finding from 1 review
Intervention not reported
Symptoms of dependence at short‐term · adults with cannabis use disorder or frequent cannabis use
The intervention may leads to higher symptoms of dependence at short‐term (low certainty).
1 finding from 1 review
Intervention not reported
Cannabis‐related problems at short‐term · adults with cannabis use disorder or frequent cannabis use
The intervention may leads to higher cannabis‐related problems at short‐term (low certainty).
1 finding from 1 review
Intervention not reported
Retention in treatment · adults with cannabis use disorder or frequent cannabis use
1 finding from 1 review
Dropout · patients with the treatment of cocaine dependence
Any antipsychotic probably leads to lower dropouts Number of participants who dropped out from the study compared with placebo (moderate certainty).
1 finding from 1 review
Participants with at least some Side Effects · patients with the treatment of cocaine dependence
Any antipsychotic showed no clear difference in side effects Number of participants with at least i side effect compared with placebo (low certainty).
1 finding from 1 review
Number of participants using cocaine during the treatment (as days/week by urine tests or self report) Number of participants that reported the use of cocaine during the treatment · patients with the treatment of cocaine dependence
Any antipsychotic showed no clear difference in number of participants using cocaine during the treatment (as… compared with placebo (low certainty).
1 finding from 1 review
Continuous abstinence (number of participants who maintained negative drug screens for 2 ‐ 3 weeks) Number of participants that maintained negative cocaine screens for at least 2 ‐ 3 weeks · patients with the treatment of cocaine dependence
Any antipsychotic showed no clear difference in continuous abstinence (number of participants who maintained… compared with placebo (low certainty).
1 finding from 1 review
Craving · patients with the treatment of cocaine dependence
1 finding from 1 review
Intervention not reported
Quantity of alcohol consumed · young adults aged up to 25 years
The intervention showed no clear difference in quantity of alcohol consumed (moderate certainty).
1 finding from 1 review