Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

671 questions · 731 findings · 61 reviews · Drugs and Alcohol

No studies found 57 · 7.8%GRADE not reported 39 · 5.3%Very low 186 · 25.4%Low 239 · 32.7%Moderate 171 · 23.4%High 39 · 5.3%

Supervised dosing with a long‐acting medication vs unsupervised consumption

Retention [ · patients with opioid dependence

Supervised dosing with a long‐acting medication showed no clear difference in retention ‐ retention at the end of treatment (number of participants) compared with unsupervised consumption (low certainty).

2 findings from 1 review

Supervised dosing with a long‐acting medication vs unsupervised consumption

Adverse serious events (any) (number of participants) · patients with opioid dependence

It is very uncertain whether supervised dosing with a long‐acting medication changes adverse serious events (any) (number of participants) compared with unsupervised consumption (very low certainty).

1 finding from 1 review

High NSP coverage vs no/low NSP coverage

HCV incidence adjusted analyses number of HCV seroconversion · people who inject drugs

It is very uncertain whether high NSP coverage changes HCV incidence adjusted analyses number of HCV seroconversion compared with no/low NSP coverage (very low certainty).

1 finding from 1 review

Combined OST and high NSP vs no OST and low/no NSP

HCV incidence adjusted analyses number of HCV seroconversion · people who inject drugs

Combined OST and high NSP may leads to lower HCV incidence adjusted analyses number of HCV seroconversions compared with no OST and low/no NSP (low certainty).

1 finding from 1 review