Findings

What do systematic reviews say?

4,317 questions · 75,239 findings · 5,342 reviews

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No studies found 15,213 · 20.2%GRADE not reported 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

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Bisphosphonates vs control

Non‐vertebral fractures · adults with cystic fibrosis who have not had a lung transplant

1 finding from 1 review

Bisphosphonates for osteoporosis in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 95 participants
Very low

Bisphosphonates vs control

BMD: % change in BMD at the lumbar spine · adults with cystic fibrosis who have not had a lung transplant

1 finding from 1 review

Bisphosphonates for osteoporosis in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 171 participants
Low

Bisphosphonates vs control

BMD: % change in BMD at the hip or femur · adults with cystic fibrosis who have not had a lung transplant

1 finding from 1 review

Bisphosphonates for osteoporosis in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 155 participants
Low

Bisphosphonates vs control

QoL · adults with cystic fibrosis who have not had a lung transplant

1 finding from 1 review

Bisphosphonates for osteoporosis in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 47 participants
Low

Bisphosphonates vs control

Adverse events: bone pain (all routes of bisphosphonate administration) · adults with cystic fibrosis who have not had a lung transplant

1 finding from 1 review

Bisphosphonates for osteoporosis in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 206 participants
Moderate

Bisphosphonates vs placebo

New vertebral fractures · children with cystic fibrosis who have not had a lung transplant

Bisphosphonates showed no clear difference in new vertebral fractures compared with placebo (low certainty).

1 finding from 1 review

Bisphosphonates for osteoporosis in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
OR 0.32 [0.03, 3.13]
1 study · 113 participants
Low

Bisphosphonates vs placebo

Non‐vertebral fractures · children with cystic fibrosis who have not had a lung transplant

Bisphosphonates showed no clear difference in new non‐vertebral fractures compared with placebo (low certainty).

1 finding from 1 review

Bisphosphonates for osteoporosis in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
OR 0.19 [0.01, 4.04]
1 study · 113 participants
Low

Bisphosphonates vs placebo

BMD: % change in BMD at the lumbar spine · children with cystic fibrosis who have not had a lung transplant

1 finding from 1 review

Bisphosphonates for osteoporosis in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 113 participants
Low

CCPT vs PEP

FEV1 (% predicted): mean change from baseline · adults and children with cystic fibrosis

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 169 participants
Very low

CCPT vs extrapulmonary mechanical percussion

FEF25–75: rate of decline in FEF25–75 · adults and children with cystic fibrosis

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 151 participants
Very low

CCPT vs extrapulmonary mechanical percussion

Time to first exacerbation requiring intravenous antibiotics · adults and children with cystic fibrosis

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 151 participants
Very low

CCPT vs extrapulmonary mechanical percussion

QoL · adults and children with cystic fibrosis

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 151 participants
Very low

CCPT vs extrapulmonary mechanical percussion

Adherence to therapy and individual preference · adults and children with cystic fibrosis

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 131 participants
Very low

CCPT vs extrapulmonary mechanical percussion

Mucus weight · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CCPT vs ACBT

Annual rate of change in % predicted FEV1 All participants · adults and children with cystic fibrosis

It is very uncertain whether CCPT changes FEV1: annual decline in FEV1 % predicted compared with ACBT (very low certainty).

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
MD 2.8
1 study · 63 participants
Very low

CCPT vs ACBT

Annual rate of change in % predicted FVC Subgroup: Under 13 years of age · adults and children with cystic fibrosis

It is very uncertain whether CCPT changes FVC: annual decline in FVC % predicted compared with ACBT (very low certainty).

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
MD 1.8
1 study · 63 participants
Very low

CCPT vs ACBT

FEF25–75: annual decline in FEF25–75 % predicted · adults and children with cystic fibrosis

It is very uncertain whether CCPT changes FEF25–75: annual decline in FEF25–75 % predicted compared with ACBT (very low certainty).

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
MD 6 [0.55, 11.45]
1 study · 63 participants
Very low

CCPT vs ACBT

Respiratory exacerbations: time to first exacerbation · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CCPT vs ACBT

QoL · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CCPT vs PEP

FVC (% predicted) Change from baseline · adults and children with cystic fibrosis

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 169 participants
Very low