Findings

What do systematic reviews say?

4,860 questions · 64,864 findings · 4,913 reviews · Headline outcomes only

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No studies found 13,869 · 21.4%GRADE not reported 3,491 · 5.4%Very low 16,300 · 25.1%Low 17,338 · 26.7%Moderate 10,900 · 16.8%High 2,966 · 4.6%

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Esomeprazole vs placebo

Endoscopic metrics ‐ not measured · GORD in infants

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Rabeprazole at higher doses (1 mg/kg) vs rabeprazole at lower doses (0.5 mg/kg)

Improvement in symptoms · GORD in children over 1 year of age

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 127 participants
Very low

Rabeprazole at higher doses (1 mg/kg) vs rabeprazole at lower doses (0.5 mg/kg)

Adverse events · GORD in children over 1 year of age

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 127 participants
Very low

Rabeprazole at higher doses (1 mg/kg) vs rabeprazole at lower doses (0.5 mg/kg)

Endoscopic improvement (dichotomous) · GORD in children over 1 year of age

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 127 participants
Very low

Rabeprazole at higher doses (1 mg/kg) vs rabeprazole at lower doses (0.5 mg/kg)

pH indices ‐ not measured · GORD in children over 1 year of age

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pantoprazole in higher doses (1.2 mg/kg) vs pantoprazole at lower doses (0.3 mg/kg)

Improvement in symptoms · GORD in children over 1 year of age

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Pantoprazole in higher doses (1.2 mg/kg) vs pantoprazole at lower doses (0.3 mg/kg)

Adverse events · GORD in children over 1 year of age

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Pantoprazole in higher doses (1.2 mg/kg) vs pantoprazole at lower doses (0.3 mg/kg)

Improvement in pH indices ‐ not measured · GORD in children over 1 year of age

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Omeprazole vs placebo

Adverse events ‐ not reported · GORD in infants

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pantoprazole in higher doses (1.2 mg/kg) vs pantoprazole at lower doses (0.3 mg/kg)

Endoscopic metrics ‐ not measured · GORD in children over 1 year of age

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Omeprazole vs placebo

Improvement in pH metrics in infants · GORD in infants

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Omeprazole vs placebo

Endoscopic metrics ‐ not measured · GORD in infants

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Omeprazole vs ranitidine

Improvement in symptoms in infants · GORD in infants

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Omeprazole vs ranitidine

Adverse events in infants ‐ not measured · GORD in infants

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Omeprazole vs ranitidine

Improvement in pH metrics in infants ‐ not measured · GORD in infants

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Omeprazole vs ranitidine

Improvement in endoscopic findings in infants ‐ not measured · GORD in infants

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Esomeprazole vs placebo

Improvement in symptoms and signs in infants · GORD in infants

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 52 participants
Very low

Statins vs placebo

Resumption of menstrual regularity · women with polycystic ovary syndrome not actively trying to conceive

1 finding from 1 review

Statins for women with polycystic ovary syndrome not actively trying to conceive 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Very low

Statin plus metformin vs metformin

Improvement in acne severity · women with polycystic ovary syndrome not actively trying to conceive

1 finding from 1 review

Statins for women with polycystic ovary syndrome not actively trying to conceive 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 69 participants
Very low

Statin plus metformin vs metformin

Improvement in testosterone level (nmol/L) after 6 months' treatment · women with polycystic ovary syndrome not actively trying to conceive

1 finding from 1 review

Statins for women with polycystic ovary syndrome not actively trying to conceive 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 69 participants
Very low