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Evidence found and GRADE certainty

3,556 questions · 10,375 findings · 429 reviews · All outcomes

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No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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Clobetasol propionate 0.025% microspheres vs Clobetasol propionate 0.025% ointment

Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Clobetasol propionate 0.025% microspheres led to higher pain (mean score) compared with clobetasol propionate 0.025% ointment; GRADE not reported.

1 finding from 1 review

Topical clobetasol propionate vs Topical ciclosporin

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical clobetasol propionate changes clinical resolution compared with topical ciclosporin (very low certainty).

1 finding from 1 review

Camouflage syringe vs Conventional syringe

Self- or observational assessment of intraoperative distress/pain/acceptance of treatment during provision of LA: pain-related behaviour (crying) · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

It is very uncertain whether camouflage syringe changes self- or observational assessment of intraoperative… compared with conventional syringe (very low certainty).

1 finding from 1 review

Clinical examination with risk-based recall vs Clinical examination with 6-month recall

Periodontitis (probing pocket depth) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with risk-based recall showed no clear difference in periodontal disease: probing pocket depth (mm) compared with clinical examination with 6-month recall (high certainty).

1 finding from 1 review

Metronidazole + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether metronidazole + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review

Antimicrobial mouthwash and/or nasal spray (alone or in combination), any concentration, frequency or dosage vs No treatment or saline or water

Anosmia (or disturbance in sense of smell) · Patients with suspected or confirmed COVID-19 infection

The review found no eligible studies for this question.

1 finding from 1 review

Pre-cooling of the injection site vs Conventional treatment

Intraoperative pain · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
1 finding from 1 review

rs1126478, additive (per-allele) model vs A allele

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

The additive-model association remained non-significant after excluding the adult-data study (OR 1.47, 95% CI 0.92 to 2.35; ungraded).

1 finding from 1 review

Chlorhexidine (mouthrinse or gel), as part of oral hygiene care vs placebo or usual care

Duration of mechanical ventilation · Critically ill patients (adults and children) receiving mechanical ventilation in ICU

It is very uncertain whether chlorhexidine (mouthrinse or gel), as part of oral hygiene care changes duration of mechanical ventilation compared with placebo or usual care (very low certainty).

1 finding from 1 review

Electrical counter-stimulation device (DentalVibe) vs Conventional treatment (no stimulation)

Completion of dental treatment · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review