Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,323 questions · 5,762 findings · 263 reviews · Dental caries

No studies found 321 · 5.6%GRADE not reported 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%

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Metal-free implant abutments (zirconia) vs Metal implant abutments (titanium)

Periodontal or peri-implant status: gingival recession (REC) · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown

Metal-free implant abutments (zirconia) showed no clear difference in gingival/mucosal recession (REC) compared with metal implant abutments (titanium); GRADE not reported.

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Caries experience (mean DMFT) · Older people (aged 60 years or older) with dementia

The DMFT index was similar between groups, with only 1 of 5 comparative studies finding a significant difference; no meta-analysis was performed (ungraded).

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Denture use (prevalence) · Older people (aged 60 years or older) with dementia

Denture use was similar in older people with and without dementia, though one study reported lower denture use with more severe dementia; no meta-analysis was performed (ungraded).

1 finding from 1 review

Metal-free tooth-supported FDPs (pressed veneering ceramic) vs Metal-free tooth-supported FDPs (layered veneering ceramic)

Periodontal/peri-implant status (secondary outcomes) · Adults (18 years or older) needing a three-unit tooth-supported fixed dental prosthesis
1 finding from 1 review
  • No comparative data were presented for the pre-specified secondary outcomes. The trial analyzed and reported plaque index, bleeding on probing and pocket probing depth but no between-group estimate was presented in the…
    1 study
    GRADE not reported

Metal-free implant abutments (zirconia) vs Metal implant abutments (titanium)

Abutment failure · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown

It is very uncertain whether metal-free implant abutments (zirconia) changes abutment failure compared with metal implant abutments (titanium) (very low certainty).

1 finding from 1 review

Metal-free FDPs (zirconia ceramic) vs Metal-ceramic FDPs

Periodontal/peri-implant status (secondary outcomes) · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)

The review found no eligible studies for this question.

1 finding from 1 review
  • No data were presented for any of the pre-specified secondary outcomes. The trial registered pocket depth, bleeding on probing and mobility at follow-up visits but did not report the data.
    0 studies
    No studies found

Metal-free cantilevered FDPs (feldspathic-veneered zirconia) vs Metal-ceramic cantilevered FDPs

Cantilevered bridge complications · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis

It is very uncertain whether metal-free cantilevered FDPs (feldspathic-veneered zirconia) changes cantilevered bridge complications compared with metal-ceramic cantilevered FDPs (very low certainty).

1 finding from 1 review

Metal-free implant-supported single crowns (zirconia veneered with feldspathic ceramic) vs Metal-ceramic implant-supported single crowns

Patient satisfaction (measured by patient satisfaction or aesthetic scales) · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown

It is very uncertain whether metal-free implant-supported single crowns (zirconia veneered with… changes aesthetic evaluation (patient satisfaction VAS) compared with metal-ceramic implant-supported single crowns (very low certainty).

2 findings from 1 review

Metal-free single crowns (full-contour zirconia) vs Cast gold (conventional metal) single crowns

Crown complications · Adults (18 years or older) needing a single crown in the molar or premolar region

It is very uncertain whether metal-free single crowns (full-contour zirconia) changes crown complications compared with cast gold (conventional metal) single crowns (very low certainty).

2 findings from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Fluorosis (mandibular teeth) at 5 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

It is very uncertain whether fluoride supplementation (tablets, drops, lozenges or chewing gum) changes fluorosis (mandibular teeth) at 5 years compared with placebo or no treatment (very low certainty).

1 finding from 1 review

ART using resin-modified glass ionomer cement (RM-GIC) vs Conventional treatment using RM-GIC

Secondary caries · Older adults with root caries in permanent (mature) teeth (mean age 75 years)
1 finding from 1 review

Glass ionomer-based sealant vs No sealant (control/no treatment)

Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review
  • Inconclusive results: two studies slightly favoured glass ionomers (Liu 2014b OR 0.46 (0.23-0.91); Tagliaferro 2011) evaluating 426 children; one study (Songpaisan 1995) found no difference (MD DFS -0.18 (-0.39 to…
    3 studies · 830 participants
    Very low

Dementia (any type or severity) vs Older people without dementia

Dental caries: prevalence of root caries · Older people (aged 60 years or older) with dementia

Root caries was higher in older people with dementia (0.6 to 4.9) than without (0.3 to 1.7), described as significantly more common but not pooled (ungraded).

1 finding from 1 review

Metal-free implant abutments (zirconia) vs Metal implant abutments (titanium)

Implant probing pocket depth (PPD) · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown

Metal-free implant abutments (zirconia) showed no clear difference in implant probing pocket depth (PPD) compared with metal implant abutments (titanium); GRADE not reported.

1 finding from 1 review

High-viscosity glass-ionomer ART restorations vs Conventional treatment using RM-GIC

Restoration failure (permanent, mature teeth) · Adults with root caries in permanent (mature) teeth

ART using H-GIC showed no clear difference in restoration failure (permanent, mature teeth) compared with conventional treatment using RM-GIC (with local anaesthetic); GRADE not reported.

1 finding from 1 review