Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,323 questions · 5,762 findings · 263 reviews · Dental caries

No studies found 321 · 5.6%GRADE not reported 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%

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Biodentine vs Propolis

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Biodentine showed no clear difference in clinical failure compared with propolis; GRADE not reported.

1 finding from 1 review

Vitapex (calcium hydroxide/iodoform) vs Sealapex (eugenol-free calcium hydroxide)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Vitapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with sealapex (eugenol-free calcium hydroxide); GRADE not reported.

1 finding from 1 review

Fluoride varnish vs Fluoride in rinse

Caries increment, surface index D(M)FS · Children or adolescents

The illustrative network meta-regression estimated an SMD for caries increment for fluoride in varnish versus fluoride in rinse across randomization year; the review did not state whether the difference was significant and certainty was not graded.

1 finding from 1 review

Non-rinse conditioner + acetone-based total-etch adhesive vs Acetone-based total-etch adhesive

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether non-rinse conditioner + acetone-based total-etch adhesive changes radiological failure compared with acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Fluoride varnish vs placebo

Caries increment, surface index D(M)FS · Children or adolescents

In the illustrative network meta-regression the SMD for caries increment showed a treatment-by-year interaction and differed between fluoride in varnish and placebo at randomization years 1954 to 1980; certainty was not graded.

1 finding from 1 review

Metal-free implant-supported FDPs (zirconia-toughened alumina; In-Ceram Zirconia) vs Metal-free implant-supported FDPs (yttria-stabilized tetragonal zirconia; Denzir)

Periodontal/peri-implant status (secondary outcomes) · Adults (18 years or older) needing an implant-supported fixed dental prosthesis in the posterior region

The review found no eligible studies for this question.

1 finding from 1 review

High-viscosity glass-ionomer ART restorations vs Conventional treatment using H-GIC (rotary instruments)

Discomfort associated with the procedure · People with dental caries in primary teeth (mainly children)

ART using high-viscosity glass ionomer cement (H-GIC), hand… showed no clear difference in participant experience (discomfort during procedure) compared with conventional treatment using H-GIC (rotary instruments); GRADE not reported.

1 finding from 1 review

ART using composite resin vs Conventional treatment using composite resin

Participant experience (dental anxiety) · Children with carious primary teeth

ART using composite resin showed no clear difference in participant experience (dental anxiety) compared with conventional treatment using composite resin; GRADE not reported.

1 finding from 1 review

Metal-free implant abutments (zirconia) vs Metal implant abutments (titanium)

Marginal bone level change · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown

Metal-free implant abutments (zirconia) showed no clear difference in marginal bone level change (MBLC) compared with metal implant abutments (titanium); GRADE not reported.

2 findings from 1 review

Metal-free implant-supported FDPs (zirconia-toughened alumina; In-Ceram Zirconia) vs Metal-free implant-supported FDPs (yttria-stabilized tetragonal zirconia; Denzir)

Bridge complications · Adults (18 years or older) needing an implant-supported fixed dental prosthesis in the posterior region

It is very uncertain whether metal-free implant-supported FDPs (zirconia-toughened alumina;… changes bridge complications compared with metal-free implant-supported FDPs (yttria-stabilized tetragonal… (very low certainty).

4 findings from 1 review
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High-viscosity glass-ionomer ART restorations vs Amalgam restoration

Restoration failure (primary dentition) · Children with carious primary teeth

ART using H-GIC showed no clear difference in restoration failure (primary teeth) compared with conventional treatment using amalgam; GRADE not reported.

1 finding from 1 review

Metal-free cantilevered FDPs (feldspathic-veneered zirconia) vs Metal-ceramic cantilevered FDPs

Plaque · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis

Metal-free cantilevered FDPs (feldspathic-veneered zirconia) showed no clear difference in plaque index (PI) compared with metal-ceramic cantilevered FDPs; GRADE not reported.

1 finding from 1 review