Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,252 questions · 2,353 findings · 210 reviews · Neonatal

No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Neonatal mortality · preterm infants at risk of respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Mortality before hospital discharge · preterm infants at risk of respiratory distress syndrome

It is very uncertain whether surfactant treatment guided by rapid tests for surfactant deficiency changes mortality prior to hospital discharge№ of participants: 562 (3 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (very low certainty).

1 finding from 1 review

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Bronchopulmonary dysplasia · preterm infants at risk of respiratory distress syndrome

Surfactant treatment guided by rapid tests for surfactant deficiency showed no clear difference in bronchopulmonary dysplasia№ of participants: 562(3 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (low certainty).

1 finding from 1 review

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Bronchopulmonary dysplasia or mortality ‐ not reported · preterm infants at risk of respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Surfactant utilization № of participants: 562 (3 RCTs) · preterm infants at risk of respiratory distress syndrome

Surfactant treatment guided by rapid tests for surfactant deficiency showed no clear difference in surfactant utilization № of participants: 562 (3 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (low certainty).

1 finding from 1 review

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Pneumothorax · preterm infants at risk of respiratory distress syndrome

Surfactant treatment guided by rapid tests for surfactant deficiency showed no clear difference in any pneumothorax№ of participants: 506(2 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (low certainty).

1 finding from 1 review

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Neurodevelopmental outcomes · preterm infants at risk of respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Superoxide dismutase (SOD) vs placebo

Severe retinopathy of prematurity (stage II or greater)№ of participants: 244(1 RCT) · preterm infants at risk for bronchopulmonary dysplasia

It is very uncertain whether superoxide dismutase (SOD) changes severe retinopathy of prematurity (stage II or greater)№ of… compared with placebo (very low certainty).

1 finding from 1 review