Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,556 questions · 10,375 findings · 429 reviews · Oral Health

No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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Vegetarian diet (any diet excluding all meat, poultry and fish) vs Nonvegetarian diet

Dental erosion · General population (children and adults) assessed for dental hard-tissue health

Among adults and excluding the outlier study, vegetarian diet was associated with higher odds of dental erosion with no heterogeneity (OR 2.56, 95% CI 1.77 to 3.71; ungraded).

4 findings from 1 review
Show 1 more finding

Clindamycin + SRP vs Doxycycline + SRP

Clinical attachment level (CAL) · Adults with aggressive periodontitis

It is very uncertain whether clindamycin + SRP changes clinical attachment level (CAL) compared with doxycycline + SRP (very low certainty).

2 findings from 1 review

CT genotype of AMELX rs6639060 vs CC genotype of AMELX rs6639060

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT genotype vs CC genotype of AMELX rs6639060 and dental caries susceptibility (CT vs CC model: OR 1.27, 95% CI 0.49-3.30) in the Age group: Adults subgroup; certainty not graded.

1 finding from 1 review

The wand (computer-controlled LA delivery system) vs other local anaesthetic

Self- or observational assessment of intraoperative distress/pain/acceptance of treatment during provision of LA: pain-related behaviour (any disruptive behaviour/sudden reaction/movement) · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
1 finding from 1 review

Vegetarian diet (any diet excluding all meat, poultry and fish) vs Nonvegetarian diet

Noncarious/cervical lesions and tooth wear (measures other than pooled dental erosion) · General population (children and adults) assessed for dental hard-tissue health

Beyond dental erosion, vegetarians tended to have a higher prevalence of other NCCL and tooth wear than nonvegetarians, reported narratively (ungraded).

1 finding from 1 review
  • Vegetarian diet and its possible influence on dental health: A systematic literature review. 2020 All outcomes
    Multiple countries (mostly India; also Finland and other European countries, Brazil, Trinidad and Tobago); community and clinical settings
    Eleven studies reported on NCCL using six definitions (presence of NCCL, presence of dental erosion, presence and severity of tooth wear, dental abrasion, cervical buccal defects); the six reporting presence of dental…
    Studies not reported
    GRADE not reported

Fluoride varnish vs Fissure sealant (resin-based or glass ionomer)

Caries incidence of first permanent molars (FPMs) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…

After excluding the high-risk-of-bias study (Bravo 1996), fluoride varnish and fissure sealant did not differ in caries incidence of FPMs and heterogeneity fell to 0% (RR 1.05, 95% CI 0.91 to 1.22; 5 RCTs; ungraded).

2 findings from 1 review

Any method, procedure or policy to reduce contaminated aerosols in dental clinics vs Any other method, no treatment or combination of methods

Cost of the intervention · Dental healthcare providers (dentist, dental surgery assistant, dental hygienist, dental technologist, dental laboratory staff, dental…

The review found no eligible studies for this question.

1 finding from 1 review

Rubber dam vs No rubber dam

Reduction in level of contamination in aerosols (CFU) during restorative procedures at operator's occiput (RCT) · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether rubber dam changes reduction in level of contamination in aerosols (CFU) during… compared with no rubber dam (very low certainty).

1 finding from 1 review

AG + GG genotype (G-allele carriers) of ENAM rs3796704 vs AA genotype of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of ENAM rs3796704 and dental caries susceptibility (AG + GG vs AA model: OR 0.24, 95% CI 0.03-2.17) in the Ethnicity: Mixed subgroup; certainty not graded.

3 findings from 1 review

Tetracycline + SRP vs SRP

Clinical attachment level (CAL) · Adults with aggressive periodontitis

Tetracycline + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.

3 findings from 1 review

Bleaching gel with added remineralising agent (fluoride, calcium, or CPP-ACP) vs Bleaching alone (no remineralising agent)

Whitening (bleaching) efficacy · Demineralised / white-spot-lesion enamel (in vitro specimens)

Low-quality in vitro evidence indicates that adding fluoride or other remineralising agents does not impair the whitening/bleaching effect (ungraded).

1 finding from 1 review

Rubber dam vs No rubber dam

Reduction in level of contamination in aerosols (CFU) during restorative procedures at 2 metres from mouth (CCT) · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether rubber dam changes reduction in level of contamination in aerosols (CFU) during… compared with no rubber dam (very low certainty).

2 findings from 1 review

GG genotype of LTF rs1126478 vs AA genotype of LTF rs1126478

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between GG genotype vs AA genotype of LTF rs1126478 and dental caries susceptibility (GG vs AA model: OR 0.97, 95% CI 0.73-1.29) in the Ethnicity: Asian subgroup; certainty not graded.

2 findings from 1 review

Topical triamcinolone acetonide vs Intralesional BCG-polysaccharide nucleic acid (BCG-PSN)

Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in pain (mean score) compared with intralesional BCG-polysaccharide nucleic acid (BCG-PSN); GRADE not reported.

1 finding from 1 review

Clindamycin + SRP vs SRP

Clinical attachment level (CAL) · Adults with aggressive periodontitis

Clindamycin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.

3 findings from 1 review