Metapex (calcium hydroxide/iodoform) vs RC Fill (ZOE with iodoform)
Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Assessed pain, radiolucency, root resorption, filling material anomaly (Ramar 2010); no significant differences
1 study · 64 participants
GRADE not reported
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes clinical failure compared with calcium hydroxide (CH) (very low certainty).
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
2 findings from 1 review
No clinical failure in any participant (Malekafzali 2011); not estimable
1 study · 80 participants
GRADE not reported
RR 3.00 [0.13, 69.70]
1 study · 42 participants
Very low
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Biodentine showed no clear difference in clinical failure compared with tempophore; GRADE not reported.
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes clinical failure compared with non-rinse conditioner + acetone-based total-etch adhesive (very low certainty).
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Erbium:YAG laser showed no clear difference in clinical failure compared with ferric sulphate (FS); GRADE not reported.
1 finding from 1 review
Sensitivity for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, pooled sensitivity of visual detection for advanced occlusal caries was 43.7% (95% CI 37 to 51) (ungraded).
3 findings from 1 review
Sensitivity 43.7 [37, 51]
50 studies
GRADE not reported
Sensitivity 64.6 [57, 71]
94 studies
GRADE not reported
Sensitivity 75.1 [70, 81]
55 studies
GRADE not reported
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Ferric sulphate/MTA pulpotomy showed no clear difference in radiological failure compared with zinc oxide and eugenol (ZOE) pulpectomy; GRADE not reported.
1 finding from 1 review
Arrest of advanced cavitated carious lesions on any coronal surface · Primary teeth with advanced cavitated carious lesions on any coronal surface
38% SDF solution biannually compared with 12% SDF solution biannually: RR 1.29 (95% CI 1.21 to 1.38); High certainty.
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Caries increment in permanent teeth · Children or adolescents
The NMR reported a difference between fluoride in dentifrice and placebo at every displayed randomisation year; no GRADE assessment was reported.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
ProRoot MTA showed no clear difference in clinical failure compared with orthoMTA; GRADE not reported.
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Ankaferd Blood Stopper (ABS) showed no clear difference in radiological failure compared with formocresol (FC); GRADE not reported.
1 finding from 1 review
Death · Patients with severe malaria
In the illustrative network meta-regression no difference in the log odds ratio for death between artesunate and artemether was seen at any displayed average age; certainty was not graded.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Caries increment, surface index D(M)FS · Children or adolescents
The illustrative network meta-regression estimated an SMD for caries increment for fluoride in varnish versus fluoride in gel across randomization year; the review did not state whether the difference was significant and certainty was not graded.
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Mineral trioxide aggregate (MTA) vs Buffered glutaraldehyde
Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Assessed pain, soft tissue, mobility, radiolucency, root resorption, pulp canal obliteration (Goyal 2016); no clinical/radiological failure outcome; pain, mobility, radiolucency, root resorption significantly favour MTA
1 study · 60 participants
GRADE not reported
Mineral trioxide aggregate (MTA) vs Diode laser
Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Assessed pain, soft tissue, mobility, radiolucency, root resorption, premature tooth loss (Niranjani 2015); no clinical/radiological failure outcome; no significant differences (RR 0.33, 0.01 to 7.72)
1 study · 40 participants
GRADE not reported
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy showed no clear difference in clinical failure compared with 3Mix pulpectomy; GRADE not reported.
1 finding from 1 review