What do systematic reviews say?

Vitamin D plus calcium vs vitamin D

Vitamin D plus calcium may leads to higher healing of rickets (number) Definition: normal alkaline phosphatase… compared with vitamin D (low certainty).

• Vitamin D, calcium or a combination of vitamin D and calcium for the treatment of nutritional rickets in children 2020 · Cochrane Headline outcomes only
  RR 3.06 [1.49, 6.29]
  1 study · 75 participants
  Low

Vitamin D plus calcium vs vitamin D

It is very uncertain whether vitamin D plus calcium changes morbidity (number) Definition: fractures compared with vitamin D (very low certainty).

• Vitamin D, calcium or a combination of vitamin D and calcium for the treatment of nutritional rickets in children 2020 · Cochrane Headline outcomes only
  RR 0.24 [0.03, 2.08]
  1 study · 75 participants
  Very low

Intervention not reported

The review found no eligible studies for this question.

• Non‐nutritive sweeteners for diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Non‐nutritive sweeteners for diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 354 participants
  Very low

Intervention not reported

The review found no eligible studies for this question.

• Non‐nutritive sweeteners for diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Non‐nutritive sweeteners for diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 184 participants
  Very low

Intervention not reported

The review found no eligible studies for this question.

• Non‐nutritive sweeteners for diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Non‐nutritive sweeteners for diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Non‐nutritive sweeteners for diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Non‐nutritive sweeteners for diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

It is very uncertain whether the intervention changes NNS versus placebo NNS: aspartame, rebaudioside A, steviol glycoside (very low certainty).

• Non‐nutritive sweeteners for diabetes mellitus 2020 · Cochrane Headline outcomes only
  RR 0.78 [0.39, 1.56]
  3 studies · 231 participants
  Very low

Intervention not reported

The review found no eligible studies for this question.

• Non‐nutritive sweeteners for diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Non‐nutritive sweeteners for diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 participants
  GRADE not reported

Intervention not reported

• Non‐nutritive sweeteners for diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 72 participants
  Very low

Intervention not reported

• Non‐nutritive sweeteners for diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 360 participants
  Very low

Metformin vs insulin

The review found no eligible studies for this question.

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs sulphonylureas

The review found no eligible studies for this question.

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs sulphonylureas

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 2940 participants
  Very low

Metformin vs sulphonylureas

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 3047 participants
  Very low

Metformin vs sulphonylureas

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 72 participants
  Very low