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Evidence found and GRADE certainty

3,323 questions · 5,762 findings · 263 reviews · Dental caries

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No studies found 321 · 5.6%GRADE not reported 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%

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Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Periodontitis (probing pocket depth) · Adults, 16 years and older (dentate)

Interdental brushing plus toothbrushing showed no clear difference in periodontitis (probing pocket depth) compared with flossing plus toothbrushing (low certainty).

1 finding from 1 review

Intervention not reported

Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes

Caries prevalence was lower in those with mean age >10 years at 57% (95% CI 0.45 to 0.68); certainty not graded.

1 finding from 1 review

30% silver diamine fluoride vs Glass ionomer cement (GIC)

Coronal carious lesions prevention · Children with coronal carious lesions (primary dentition)

One review reported glass ionomer cement was more effective than 30% SDF at 12 months (PF −6%), but the difference was not statistically significant (ungraded).

1 finding from 1 review

Fluoride varnish vs no treatment

Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth)

5% NaF varnish may be more effective than no treatment for arrest or reversal of facial/lingual carious lesions (RR 2.3, 95% CI 1.58 to 3.34; low certainty).

1 finding from 1 review

Patient-used 5000 ppm F toothpaste, daily vs 1450 to 1500 ppm F toothpaste

Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth)

Adverse events · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth

The review found no eligible studies for this question.

1 finding from 1 review

1450 to 1500 ppm F toothpaste vs 440 to 550 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1450 to 1500 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with 440 to 550 ppm F toothpaste (low certainty).

1 finding from 1 review

1700 to 2200 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1700 to 2200 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 1000 to 1250 ppm F toothpaste (low certainty).

1 finding from 1 review

Fluoride varnish vs no treatment

Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)

5% NaF varnish was probably more effective than no treatment for arrest or reversal of occlusal carious lesions (RR 1.97, 95% CI 1.63 to 2.4; moderate certainty).

1 finding from 1 review

Patient-used 5000 ppm F toothpaste, daily vs 1450 to 1500 ppm F toothpaste

Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Patient-used 5000 ppm F toothpaste, daily throughout treatment showed no clear difference in number of participants with new demineralised lesions (DLs) compared with 1450 ppm F (conventional) toothpaste, daily (low certainty).

1 finding from 1 review

Professionally-applied 12,300 ppm F APF foam, every 2 months vs 0 ppm F placebo foam

Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

0.2% NaF mouthrinse + supervised toothbrushing vs no treatment

Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)

0.2% NaF mouthrinse + supervised toothbrushing was probably more effective than no treatment for arrest or reversal of occlusal carious lesions (RR 1.94, 95% CI 1.54 to 2.46; moderate certainty).

1 finding from 1 review

Intervention not reported

Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes

Caries prevalence was higher in those with mean age <=10 years at 80% (95% CI 0.74 to 0.85); certainty not graded.

1 finding from 1 review

1700 to 2200 ppm F toothpaste vs 440 to 550 ppm F toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1700 to 2200 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with 440 to 550 ppm F toothpaste (low certainty).

1 finding from 1 review

Fluoride varnish vs no treatment

Arrest or reversal of noncavitated carious lesions on any coronal surface · Children and adults with noncavitated carious lesions on any coronal surface (primary and permanent teeth)

5% NaF varnish was probably more effective than no treatment for arrest or reversal of any-coronal carious lesions (RR 2.15, 95% CI 1.8 to 2.57; moderate certainty).

1 finding from 1 review

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Periodontal conditions (gingival inflammation, bleeding on probing, probing depth, clinical attachment loss) · Children and adolescents with juvenile idiopathic arthritis (JIA)

Periodontal conditions (gingival inflammation, bleeding, probing depth, attachment loss) were more frequently reported in children/adolescents with JIA than in healthy peers, although not all studies agreed; no pooled estimate (ungraded).

1 finding from 1 review