Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,556 questions · 10,375 findings · 429 reviews · Oral Health

No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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Fluorescence-based devices vs Visual classification

Difference in specificity · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies)

Fluorescence and visual classification had similar specificity in the fully within-person analysis.

1 finding from 1 review

Fluoride concentration relative to the acceptable range (electrometric ion-selective electrode measurement; acceptable range mostly 0.6-0.8 ppmF) vs None (descriptive proportion meta-analysis)

Water samples with fluoride concentration above the acceptable range · Artificially fluoridated public water supply in Brazilian cities (water samples under external control)

In the Southeast Brazilian region, a pooled 11.5% of water samples had fluoride above the acceptable range; ungraded.

2 findings from 1 review

COE with light-based detection (e.g. ViziLite Plus, Microlux/DL, VELscope, Identafi 3000) vs Reference standard: examination and clinical evaluation by a physician/clinician with specialist knowledge or training (long-term follow-up accepted for those screened negative)

Outcome not reported · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…

The review found no eligible studies for this question.

1 finding from 1 review

Fixed tooth-borne expansion (Hyrax) vs observation

Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

Fixed tooth-borne expansion (Hyrax) probably leads to higher molar expansion (inter-molar distance) compared with observation (no treatment) (moderate certainty).

1 finding from 1 review

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Pain (dichotomous, present/absent on 6th-7th day) · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes presence of pain (dichotomous, yes/no on 6th-7th day) compared with placebo (very low certainty).

1 finding from 1 review

Dental fluorosis assessment vs None (descriptive prevalence review; subgroup analyses by urban/rural status, country and year)

Dental fluorosis prevalence · School-aged children in the United Arab Emirates (Dubai)

One study reported dental fluorosis in 10.9% of school-aged children in Dubai, mostly very mild or mild (narrative synthesis; not GRADE-rated).

1 finding from 1 review

ARP with allograft (bone graft) vs ARP with xenograft

Changes in bucco-lingual/palatal width of alveolar ridge (mm) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

It is very uncertain whether ARP with allograft changes changes in bucco-lingual/palatal width of alveolar ridge (mm) compared with ARP with xenograft (very low certainty).

1 finding from 1 review

Rubber dam vs Isolite system

Costs: operation/chair time · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)

It is very uncertain whether rubber dam isolation changes costs: operation/chair time compared with isolite system (very low certainty).

1 finding from 1 review

Cone beam computed tomography (CBCT) vs Digital radiographs (direct within-person / paired comparison); reference standard: histology

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
2 findings from 1 review

Eruption guidance appliance vs No active treatment (control)

Amount of crowding (number of children with crowding, mandible) after 1 year · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether eruption guidance appliance changes amount of crowding (number of children with crowding, mandible)… compared with no active treatment (control) (very low certainty).

1 finding from 1 review

Bone-borne expansion vs observation

Crossbite correction · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review
  • Orthodontic treatment for posterior crossbites 2021 · Cochrane All outcomes
    Adolescents
    Alberta 2010: bone-borne expansion corrected all posterior crossbites (21/21); no self-correction in the untreated group
    1 study
    GRADE not reported

Compomer (polyacid-modified composite, fluoride-releasing) for bonding brackets vs Compomer bonding agent without fluoride release

Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances

For compomer-based bonding agents, fluoride release did not significantly change WSL initiation (RR 0.71); subgroup not separately GRADE-rated.

1 finding from 1 review

ARP with alloplast vs ARP with xenograft

Changes in vertical height of alveolar ridge (mm) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

It is very uncertain whether ARP with alloplast changes changes in vertical height of alveolar ridge (mm) compared with ARP with xenograft (very low certainty).

1 finding from 1 review