Care index (CI), permanent teeth · Children aged 1-18 years
The care index (met dental care need) for permanent teeth could not be meta-analyzed because no study reported variance; it was lower or equal in children with learning disabilities in 5 of 8 studies (certainty not graded).
1 finding from 1 review
Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth)
5% NaF varnish may not differ from Resin infiltration for arrest or reversal of approximal carious lesions (RR 1.09, 95% CI 0.32 to 3.65; very low certainty).
1 finding from 1 review
Caries increment, tooth index D(M)FT · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start)
1055 to 1100 ppm F toothpaste showed no clear difference in caries increment, tooth index d(m)ft compared with 500 to 550 ppm F toothpaste (low certainty).
1 finding from 1 review
DMFT/DMFS index (dental caries experience) · Children aged 0-12 years in Japan
The single Japanese study yielded a degenerate estimate of OR 0.00 (95% CI 0.00 to 0.00; ungraded, single study).
1 finding from 1 review
Arrest of advanced cavitated carious lesions on any coronal surface · Preschool children with advanced cavitated carious lesions on any coronal surface (primary teeth)
12% SDF solution (applied annually) did not differ from 12% SDF solution (applied biannually) for arrest or reversal of cavitated coronal carious lesions (RR 0.94, 95% CI 0.87 to 1.02; high certainty).
4 findings from 1 review
Show 1 more finding
Plaque · Adults, 16 years and older (dentate)
It is very uncertain whether interdental brushing plus toothbrushing changes plaque compared with flossing plus toothbrushing (very low certainty).
Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth)
10% CPP-ACP cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) may not differ from Placebo cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) for arrest or reversal of facial/lingual carious lesions (RR 1.28, 95% CI 0.97 to 1.68; low certainty).
3 findings from 1 review
Gingival bleeding (various bleeding indices) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
It is very uncertain whether 1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily changes gingival bleeding index (mean change from baseline) compared with 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily (very low certainty).
1 finding from 1 review
Gingivitis · Adults, 16 years and older (dentate)
It is very uncertain whether rubber/elastomeric cleaning stick plus toothbrushing changes gingivitis (proportion of bleeding sites) compared with interdental brushing plus toothbrushing (very low certainty).
2 findings from 1 review
Adverse effects of toothpaste · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start)
The review found no eligible studies for this question.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single RCT found no difference in pulpotomy success between MTA and calcium-enriched mixture (both 100% at 6 and 12 months; not pooled; ungraded).
1 finding from 1 review
Single RCT (Nosrat 2012, 118 roots): 100% clinical and radiographic success in both MTA and CEM at 6 and 12 months (MTA 53/53 then 54/54 roots; CEM 55/55 then 57/57 roots); no statistical difference between groups at…
1 study · 118 participants
GRADE not reported
Plaque · Medically healthy individuals (adults and children, 6-60 years)
Salvadora persica was less effective than 0.2% chlorhexidine at reducing plaque (favours chlorhexidine); not GRADE-rated.
1 finding from 1 review
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1000 to 1250 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with 250 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.15 [-0.31, 0.0]
3 studies
Low
Lactobacillus count (CFU/mL) · Medically healthy individuals (adults and children, 6-60 years)
Salvadora persica rinse reduced Lactobacillus counts more than placebo (favours Salvadora persica); not GRADE-rated.
1 finding from 1 review
Adverse effects of toothpaste · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start)
1 finding from 1 review
Adverse effects of toothpaste: not estimable. "There were no reports on adverse effects, but some children complained about the taste of the dentifrice" (Cardoso 2014); 195 participants (1 RCT); low-certainty.
1 study · 195 participants
Low
Dental caries · Children aged 5-7 years (early school-age)
In early school-age children (5-7 y) from heavily contaminated areas, individual studies gave conflicting DMFT/dmft differences (some favouring exposed, some non-exposed); the review did not pool them (ungraded).
4 findings from 1 review
A systematic review of the caries prevalence among children living in Chernobyl fallout countries. 2019 All outcomesChernobyl fallout areas, Eastern Europe (Ukraine, Belarus, Russian Federation) · heavy contamination
WMD -0.81 [-1.06, -0.56]
1 study · 80 participants
GRADE not reported
A systematic review of the caries prevalence among children living in Chernobyl fallout countries. 2019 All outcomesChernobyl fallout areas, Eastern Europe (Ukraine, Belarus, Russian Federation) · heavy contamination
WMD -1.03 [-1.36, -0.70]
1 study · 78 participants
GRADE not reported
A systematic review of the caries prevalence among children living in Chernobyl fallout countries. 2019 All outcomesChernobyl fallout areas, Eastern Europe (Ukraine, Belarus, Russian Federation) · heavy contamination
WMD 1.75 [1.73, 1.77]
1 study · 1474 participants
GRADE not reported
Show 1 more finding
White spot lesion index (mean change from baseline) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
It is very uncertain whether 1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily changes white spot lesion index (mean change from baseline) compared with 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily (very low certainty).
1 finding from 1 review
Caries increment, surface index D(M)FS · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start)
1055 to 1100 ppm F toothpaste showed no clear difference in caries increment, surface index d(m)fs compared with 500 to 550 ppm F toothpaste (moderate certainty).
1 finding from 1 review
Plaque · Adults, 16 years and older (dentate)
Oral irrigation plus toothbrushing showed no clear difference in plaque compared with toothbrushing alone (low certainty).
1 finding from 1 review
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1700 to 2200 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).
1 finding from 1 review
SMD -0.32 [-0.41, -0.22]
Studies not reported
Low