Incidence of depression ‐ medium term: 6‐12 months · adults with long‐term physical conditions (18 years or older)
1 finding from 1 review
Incidence of depression ‐ long term: > 12 months · adults with long‐term physical conditions (18 years or older)
1 finding from 1 review
Tolerability ‐ total number of adverse events · adults with long‐term physical conditions (18 years or older)
1 finding from 1 review
Adverse effects (drop‐outs due to adverse effects4) · adults with long‐term physical conditions (18 years or older)
1 finding from 1 review
Acceptability · adults with long‐term physical conditions (18 years or older)
Psychological interventions may leads to higher acceptability ‐ drop‐outs due to any cause: post‐intervention compared with treatment (low certainty).
2 findings from 1 review
Incidence of depression ‐ post‐intervention: 0 months · adults with long‐term physical conditions (18 years or older)
It is very uncertain whether pharmacological interventions changes incidence of depression ‐ post‐intervention: 0 months compared with placebo (very low certainty).
1 finding from 1 review
Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults (aged 18 years+) with depression in bipolar disorder
Ketamine may leads to higher efficacy: number of participants who respond to treatment ‐ at 24… compared with placebo (low certainty).
1 finding from 1 review
Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder
1 finding from 1 review
Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether memantine changes efficacy: number of participants who respond to treatment ‐ at 1 week compared with placebo (very low certainty).
4 findings from 1 review
OR 1.08 [0.06, 19.05]
1 study · 29 participants
Very low
OR 4.88 [0.78, 30.29]
1 study · 29 participants
Very low
OR 5.33 [1.02, 27.76]
1 study · 29 participants
Very low
Show 1 more finding
Remission · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether memantine changes efficacy: number of participants who achieve remission ‐ at 1 week compared with placebo (very low certainty).
1 finding from 1 review
Depressive symptoms · adults (aged 18 years+) with depression in bipolar disorder
1 finding from 1 review
Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder
Memantine showed no clear difference in acceptability: total dropouts compared with placebo (low certainty).
1 finding from 1 review
Acceptability ‐ dropouts due to adverse effects · adults (aged 18 years+) with depression in bipolar disorder
Memantine showed no clear difference in acceptability: dropouts due to adverse effects compared with placebo (low certainty).
1 finding from 1 review
Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether cytidine changes efficacy: number of participants who respond to treatment ‐ at 3… compared with placebo (very low certainty).
1 finding from 1 review
Remission · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether ketamine changes efficacy: number of participants who achieve remission ‐ at 1 week compared with placebo (very low certainty).
1 finding from 1 review
Remission · adults (aged 18 years+) with depression in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Depression rating scale score · adults (aged 18 years+) with depression in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether cytidine changes acceptability: total dropouts compared with placebo (very low certainty).
1 finding from 1 review
Acceptability ‐ dropouts due to adverse effects · adults (aged 18 years+) with depression in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder
N‐acetylcysteine showed no clear difference in efficacy: number of participants who respond to treatment ‐ at 3… compared with placebo (low certainty).
1 finding from 1 review