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Evidence found and GRADE certainty

3,323 questions · 5,762 findings · 263 reviews · Dental caries

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No studies found 321 · 5.6%GRADE not reported 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%

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CT genotype of ENAM rs3796703 vs CC genotype of ENAM rs3796703

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT genotype vs CC genotype of ENAM rs3796703 and dental caries susceptibility (CT vs CC model: OR 0.89, 95% CI 0.23-3.48) in the Ethnicity: Asian subgroup; certainty not graded.

3 findings from 1 review

Canary System (Quantum Dental Technologies; red fluorescence, scale 0-100) vs Reference standard: histology, enhanced visual examination with or without radiographs, or excavation

Outcome not reported · Children or adults presenting asymptomatically or suspected of having enamel caries (in vivo/clinical studies); extracted teeth of…

The review found no eligible studies for this question.

1 finding from 1 review

All fluorescence-based devices (red, blue, and green fluorescence combined) vs Reference standard (histology, excavation, or enhanced visual examination)

Sensitivity at fixed upper-quartile specificity 0.90 (detection of early enamel caries, D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Preterm birth (<37 weeks gestation) vs Full-term birth (37 weeks or more gestation)

Early childhood caries (ECC) · Children aged 6 years or younger (preschool children)

In children aged 3 years or younger, preterm birth was not associated with early childhood caries (OR 0.90, 95% CI 0.59 to 1.37); certainty not graded.

2 findings from 1 review

TT genotype of ENAM rs3796703 vs CC genotype of ENAM rs3796703

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC genotype of ENAM rs3796703 and dental caries susceptibility (TT vs CC model: OR 5.22, 95% CI 0.25-108.96) in the Ethnicity: Asian subgroup; certainty not graded.

3 findings from 1 review

All exposure-OHRQoL estimates pooled for publication-bias correction (meta-trim sensitivity); specific exposure set not defined in source vs Not specified

Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years

A trim-and-fill sensitivity analysis pooling every exposure estimate gave an overall OR of 0.17 (95% CI 0.13-0.21) after correcting for significant publication bias (Fig. 13); this combined estimate spans heterogeneous exposures and is a publication-bias sensitivity result (ungraded).

1 finding from 1 review

Combined index test: visual examination + radiograph + DIAGNOdent (Alomari 2015) vs Reference standard: histology

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Resin-based fissure sealant plus fluoride varnish vs Fluoride varnish

Progression of dentinal carious lesions into enamel or dentine · Children and adolescents (general population, aged under 20 years)

The review found no eligible studies for this question.

1 finding from 1 review

Periodontal disease (present) vs Individuals without periodontal disease (by LOA)

Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years

Periodontal disease was associated with higher odds of poor OHRQoL (OR 1.15, 95% CI 1.12-1.18; 3 studies; no heterogeneity; ungraded).

1 finding from 1 review

CT + TT genotype (T-allele carriers) of ENAM rs3796703 vs CC genotype of ENAM rs3796703

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of ENAM rs3796703 and dental caries susceptibility (CT + TT vs CC model: OR 0.90, 95% CI 0.23-3.63); certainty not graded.

3 findings from 1 review