All‐cause mortality
0.14 [0, 6.98]
8 studies · 2175 participants
Moderate
Peto OR 1.06 [0.62, 1.82]
14 studies · 6173 participants
Low
Health‐related quality of life Scales: Well‐Being Enquiry for Diabetics; General Well‐being; Diabetes Quality of Life for Youth and Parents' Diabetes Quality of Life
1 finding from 1 review
Intervention not reported
All‐cause mortality Median · individuals without known diabetes mellitus but at high risk for the condition
The intervention showed no clear difference in all‐cause mortality Median (low certainty).
1 finding from 1 review
Intervention not reported
Diabetes‐related mortality Assessed according to whether diabetes was included anywhere on the death certificate · individuals without known diabetes mellitus but at high risk for the condition
The intervention showed no clear difference in diabetes‐related mortality Assessed according to whether diabetes… (low certainty).
1 finding from 1 review
Intervention not reported
Diabetes‐related morbidity · individuals without known diabetes mellitus but at high risk for the condition
The review found no eligible studies for this question.
1 finding from 1 review
Intervention not reported
Incidence of type 2 diabetes · individuals without known diabetes mellitus but at high risk for the condition
The review found no eligible studies for this question.
1 finding from 1 review
Intervention not reported
Health‐related quality of life · individuals without known diabetes mellitus but at high risk for the condition
The review found no eligible studies for this question.
1 finding from 1 review
Intervention not reported
Adverse events · individuals without known diabetes mellitus but at high risk for the condition
The review found no eligible studies for this question.
1 finding from 1 review
Intervention not reported
Socioeconomic effects · individuals without known diabetes mellitus but at high risk for the condition
The review found no eligible studies for this question.
1 finding from 1 review
Diabetes‐related complications (1) Fatal MI (2) Fatal stroke (3) Progression in retinopathy (4) Amputations (5) ESRD
It is very uncertain whether insulin glargine changes diabetes‐related complications (1) Fatal MI (2) Fatal stroke (3)… compared with NPH insulin (very low certainty).
1 finding from 1 review
RR 1.03 [0.6, 1.77]
1 study · 4 participants
Very low
AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading to discontinuation
Insulin detemir showed no clear difference in AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading… compared with NPH insulin (moderate certainty).
1 finding from 1 review
RR 0.88 [0.64, 1.2]
1 study · 8 participants
Moderate
Socioeconomic effects
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Hypoglycaemic episodes
It is very uncertain whether insulin glargine changes hypoglycaemic episodes(1) Severe hypoglycaemia (2) Serious… compared with NPH insulin (very low certainty).
1 finding from 1 review
Health‐related quality of life
1 finding from 1 review
AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading to discontinuation
Insulin glargine showed no clear difference in AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading… compared with NPH insulin (moderate certainty).
1 finding from 1 review
Socioeconomic effects
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Diabetes‐related complications (1) Fatal MI (2) Fatal stroke (3) Progression in retinopathy (4) Amputations (5) ESRD
It is very uncertain whether insulin detemir changes diabetes‐related complications (1) Fatal MI (2) Fatal stroke (3)… compared with NPH insulin (very low certainty).
1 finding from 1 review
RR 1.5 [0.68, 3.32]
1 study · 2 participants
Very low
Hypoglycaemic episodes
It is very uncertain whether insulin detemir changes hypoglycaemic episodes (1) Severe hypoglycaemia (2) Serious… compared with NPH insulin (very low certainty).
1 finding from 1 review
RR 0.45 [0.17, 1.2]
1 study · 5 participants
Very low
Intervention not reported
Basal calcitonin
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Reported cut‐off value (range 4.6 ‐100 pg/mL)
1 finding from 1 review