Cochrane · systematic review · CD010159
Calcitonin testing for detection of medullary thyroid cancer in people with thyroid nodules
Verbeek, HHG, de Groot, JWB, Sluiter, WJ, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Metabolic and Endocrine DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
0
No studies
4
Included studies
NR
No studies 4 · 44.4%Ungraded 5 · 55.6%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Basal calcitonin | no estimate extracted | NR | No studies |
Reported cut‐off value (range 4.6 ‐100 pg/mL) | no estimate extracted | 16 studies · 72368 participants | Ungraded |
Reported cut‐off value (range basal calcitonin 4.6 pg/mL to 35 pg/mL, range stimulated calcitonin 50 pg/mL to 100 pg/mL) | no estimate extracted | 13 studies · 69702 participants | Ungraded |
Subgroup analysis | no estimate extracted | NR | No studies |
Cut‐off value | no estimate extracted | NR | No studies |
pg/mL | no estimate extracted | 10 studies · 44393 participants | Ungraded |
Gender (basal calcitonin) | no estimate extracted | NR | No studies |
Female | no estimate extracted | 6 studies · 14858 participants | Ungraded |
Male | no estimate extracted | 6 studies · 4339 participants | Ungraded |