Kidney composite outcome median · people with diabetes and CKD
Sodium‐glucose co‐transporter protein 2 (SGLT2) inhibitors leads to lower kidney composite outcome median compared with placebo (high certainty).
1 finding from 1 review
Kidney failure · people with diabetes and CKD
Sodium‐glucose co‐transporter protein 2 (SGLT2) inhibitors leads to lower kidney failure median compared with placebo (high certainty).
1 finding from 1 review
Hypoglycaemia requiring third‐party assistance median · people with diabetes and CKD
Sodium‐glucose co‐transporter protein 2 (SGLT2) inhibitors leads to lower hypoglycaemia requiring third‐party assistance median compared with placebo (high certainty).
1 finding from 1 review
Diabetic ketoacidosis median · people with diabetes and CKD
Sodium‐glucose co‐transporter protein 2 (SGLT2) inhibitors probably leads to higher diabetic ketoacidosis median compared with placebo (moderate certainty).
1 finding from 1 review
Virologically confirmed dengue case incidence (any severity, any phenotype) · children and adults at risk of dengue infection
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Prevalence of DENV infection (any severity, any phenotype)a · children and adults at risk of dengue infection
wMel‐Wolbachia infected Aedes aegypti deployments probably leads to lower prevalence of DENV infection (any severity, any phenotype)a compared with no deployments (moderate certainty).
1 finding from 1 review
OR 0.23 [0.15, 0.35]
6306 participants
Moderate
Prevalence of dengue RNA in the mosquito population · children and adults at risk of dengue infection
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Mosquito density (for population suppression strategy) · children and adults at risk of dengue infection
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Prevalence of Wolbachia‐carrying mosquitoes (for population replacement strategy) · children and adults at risk of dengue infection
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events potentially related to Wolbachia‐carrying Aedes deployments · children and adults at risk of dengue infection
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Difference between effect estimates from RCTs and observational studies [for RCTs vs OBSs] · systematic reviews and overviews of systematic reviews
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Caries arrest · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes caries arrest compared with glass ionomer cement (GIC) plus fluoride varnish (very low certainty).
1 finding from 1 review
Range of mandibular motion · People with temporomandibular disorders (TMD)
Occlusal splint showed no clear difference in range of mandibular motion compared with another occlusal splint with a different mechanism of action; GRADE not reported.
1 finding from 1 review
Caries presence in primary teeth · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
It is very uncertain whether oral health education/promotion (oral hygiene advice plus diet and… changes caries presence in primary teeth compared with standard care (very low certainty).
1 finding from 1 review
Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask with rapid maxillary expansion (RME) may leads to higher overjet compared with facemask only (low certainty).
1 finding from 1 review
Participant satisfaction · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
The review found no eligible studies for this question.
1 finding from 1 review
Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Superelastic NiTi arch wire showed no clear difference in alignment rate compared with thermoelastic NiTi arch wire (low certainty).
1 finding from 1 review
Caries in primary teeth: dmft (3 years) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
It is very uncertain whether advice about a healthy diet (including breastfeeding promotion and… changes dmft index score (decayed, missing, filled primary teeth; range 0-20) compared with standard care (very low certainty).
1 finding from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
Goel 2015 (3-arm: intralesional betamethasone vs lycopene vs placebo, 90 per arm): appeared to show increased interincisal distance in both intervention groups vs placebo, but only between-group differences with no…
1 study · 180 participants
GRADE not reported
Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether intralesional triamcinolone changes burning sensation (VAS 0-100) compared with intralesional triamcinolone plus salvianolic acid B (very low certainty).
2 findings from 1 review
MD -1.00 [-10.37, 8.37]
1 study · 28 participants
Very low
MD -16.30 [-28.15, -4.45]
1 study · 28 participants
Very low