Findings

What do systematic reviews say?

2,510 questions · 2,653 findings · 194 reviews · Gynaecology and Fertility

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No studies found 531 · 20%GRADE not reported 76 · 2.9%Very low 826 · 31.1%Low 855 · 32.2%Moderate 341 · 12.9%High 24 · 0.9%

hCG vs GnRH agonist

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

It is very uncertain whether hCG changes multiple pregnancy rate per pregnancy compared with gnRH‐a (very low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 0.15 [0.02, 1.38]
4 studies · 74 participants
Very low

hCG vs GnRH agonist

Miscarriage · women trying to conceive by intrauterine insemination

It is very uncertain whether hCG changes miscarriage rate per pregnancy compared with gnRH‐a (very low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.72 [0.48, 6.2]
4 studies · 74 participants
Very low

hCG vs LH surge

Pregnancy rate · women trying to conceive by intrauterine insemination

hCG showed no clear difference in pregnancy rate per couple compared with LH surge (low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.33 [0.72, 2.45]
4 studies · 275 participants
Low

hCG vs GnRH agonist

OHSS · women trying to conceive by intrauterine insemination

hCG showed no clear difference in OHSS per cycle compared with gnRH‐a (low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 2.27 [0.65, 7.91]
3 studies · 456 participants
Low

Early hCG vs late hCG

Pregnancy rate · women trying to conceive by intrauterine insemination

Early hCG showed no clear difference in pregnancy rate per couple compared with late hCG (low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.32 [0.77, 2.25]
1 study · 612 participants
Low

Early hCG vs late hCG

Miscarriage · women trying to conceive by intrauterine insemination

It is very uncertain whether early hCG changes miscarriage rate compared with late hCG (very low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 0.51 [0.08, 3.28]
1 study · 65 participants
Very low

Intervention not reported

Pregnancy rate per couple · women undergoing intrauterine insemination

It is very uncertain whether the intervention changes pregnancy rate per couple (very low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.38 [0.28, 6.71]
1 study · 66 participants
Very low

hCG vs LH surge

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

It is very uncertain whether hCG changes multiple pregnancy rate per pregnancy compared with LH surge (very low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.12 [0.17, 7.6]
2 studies · 42 participants
Very low

u‐hCG vs r‐hCG

Live birth rate per couple · women trying to conceive by intrauterine insemination

u‐hCG showed no clear difference in live birth rate per couple compared with r‐hCG (low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.17 [0.68, 2.03]
1 study · 284 participants
Low

u‐hCG vs r‐hCG

Pregnancy rate · women trying to conceive by intrauterine insemination

u‐hCG showed no clear difference in pregnancy rate per couple compared with r‐hCG (low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.02 [0.65, 1.57]
2 studies · 409 participants
Low

u‐hCG vs r‐hCG

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

u‐hCG showed no clear difference in multiple pregnancy rate per pregnancy compared with r‐hCG (low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 0.99 [0.4, 2.47]
2 studies · 109 participants
Low

u‐hCG vs r‐hCG

Miscarriage · women trying to conceive by intrauterine insemination

It is very uncertain whether u‐hCG changes miscarriage rate per pregnancy compared with r‐hCG (very low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 0.57 [0.13, 2.47]
2 studies · 109 participants
Very low

u‐hCG vs r‐hCG

OHSS · women trying to conceive by intrauterine insemination

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 468 participants
Moderate

Short interval vs long interval

Live birth rate per couple · women trying to conceive by intrauterine insemination

Short interval showed no clear difference in live birth rate per couple ‐ 24 hours versus 34 to 36 hours compared with long interval (low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 0.52 [0.27, 1]
1 study · 204 participants
Low

Laparoscopy vs open appendicectomy

Diagnosis before discharge · women of childbearing age with acute lower abdominal pain

Laparoscopy probably leads to higher diagnosis before discharge compared with open appendicectomy (moderate certainty).

1 finding from 1 review

Laparoscopy for the management of acute lower abdominal pain in women of childbearing age 2014 · Cochrane Headline outcomes only
OR 4.1 [2.5, 6.71]
7 studies · 561 participants
Moderate

Laparoscopy vs open appendicectomy

Any adverse events · women of childbearing age with acute lower abdominal pain

Laparoscopy showed no clear difference in any adverse events compared with open appendicectomy (low certainty).

1 finding from 1 review

Laparoscopy for the management of acute lower abdominal pain in women of childbearing age 2014 · Cochrane Headline outcomes only
OR 0.46 [0.19, 1.1]
7 studies · 563 participants
Low

Laparoscopy vs open appendicectomy

Length of stay · women of childbearing age with acute lower abdominal pain

Laparoscopy showed no clear difference in total length of in‐patient stay (days) compared with open appendicectomy (low certainty).

1 finding from 1 review

Laparoscopy for the management of acute lower abdominal pain in women of childbearing age 2014 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 455 participants
Low

Laparoscopy vs open appendicectomy

Normal appendix removed · women of childbearing age with acute lower abdominal pain

Laparoscopy probably leads to lower normal appendix removed compared with open appendicectomy (moderate certainty).

1 finding from 1 review

Laparoscopy for the management of acute lower abdominal pain in women of childbearing age 2014 · Cochrane Headline outcomes only
OR 0.13 [0.07, 0.24]
7 studies · 475 participants
Moderate

Laparoscopy vs 'wait and see' strategy

Diagnosis before discharge · women of childbearing age with acute lower abdominal pain

Laparoscopy probably leads to higher diagnosis before discharge compared with 'wait and see' strategy (moderate certainty).

1 finding from 1 review

Laparoscopy for the management of acute lower abdominal pain in women of childbearing age 2014 · Cochrane Headline outcomes only
OR 6.07 [1.85, 19.88]
4 studies · 395 participants
Moderate

Laparoscopy vs 'wait and see' strategy

Any adverse events · women of childbearing age with acute lower abdominal pain

Laparoscopy showed no clear difference in any adverse events compared with 'wait and see' strategy (moderate certainty).

1 finding from 1 review

Laparoscopy for the management of acute lower abdominal pain in women of childbearing age 2014 · Cochrane Headline outcomes only
OR 0.87 [0.45, 1.67]
4 studies · 399 participants
Moderate