Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,293 questions · 2,395 findings · 172 reviews · Gut

No studies found 420 · 17.5%GRADE not reported 60 · 2.5%Very low 821 · 34.3%Low 602 · 25.1%Moderate 397 · 16.6%High 95 · 4%

Intervention not reported

Chemobased DFS ‐ 5‐FU based chemotherapy DFS · patients with resectable gastric cancer

The intervention probably leads to lower chemobased DFS ‐ 5‐FU based chemotherapy DFS (moderate certainty).

1 finding from 1 review

Intervention not reported

Chemobased DFS ‐ Platinum‐based chemotherapy DFS · patients with resectable gastric cancer

The intervention showed no clear difference in chemobased DFS ‐ Platinum‐based chemotherapy DFS (moderate certainty).

1 finding from 1 review

Intervention not reported

Stage OS analysis ‐ T1/2 OS · patients with resectable gastric cancer

The intervention showed no clear difference in stage OS analysis ‐ T1/2 OS (moderate certainty).

1 finding from 1 review

Intervention not reported

Stage OS analysis ‐ T3/4 OS · patients with resectable gastric cancer

The intervention showed no clear difference in stage OS analysis ‐ T3/4 OS (moderate certainty).

1 finding from 1 review

Intervention not reported

Lymph node mets analysis ‐ N‐ OS · patients with resectable gastric cancer

The intervention showed no clear difference in lymph node mets analysis ‐ N‐ OS (moderate certainty).

1 finding from 1 review

Intervention not reported

Survival · patients with unresectable periampullary carcinoma

It is very uncertain whether the intervention changes survival (very low certainty).

1 finding from 1 review

Intervention not reported

Gastric outlet obstruction Clinical symptoms of vomiting with confirmation of the gastric outlet obstruction by radiological or endoscopic investigations · patients with unresectable periampullary carcinoma

It is very uncertain whether the intervention changes gastric outlet obstruction Clinical symptoms of vomiting with… (very low certainty).

1 finding from 1 review

Morphine vs metamizole

Improvements in pain intensity as defined by the trialist (primary outcome) · participants with acute pancreatitis pain

Morphine showed no clear difference in improvements in pain intensity as defined by the trialist (primary… compared with metamizole (low certainty).

1 finding from 1 review

Opioids vs no opioids

Supplementary analgesic option offered (primary outcome 2) · participants with acute pancreatitis pain

Opioids may leads to lower supplementary analgesic option offered (primary outcome 2) compared with no opioids (low certainty).

1 finding from 1 review

Opioids vs no opioids

Pancreatitis complications (secondary outcome 1) · participants with acute pancreatitis pain

Opioids showed no clear difference in pancreatitis complications (secondary outcome 1) compared with no opioids (low certainty).

1 finding from 1 review

Opioids vs no opioids

Adverse drug events · participants with acute pancreatitis pain

Opioids showed no clear difference in any drug‐related adverse event (secondary outcome 2) compared with no opioids (low certainty).

1 finding from 1 review

Opioids vs no opioids

Nausea and vomiting · participants with acute pancreatitis pain

Opioids showed no clear difference in nausea and vomiting (secondary outcome 2) compared with no opioids (low certainty).

1 finding from 1 review

Opioids vs no opioids

Sedation and somnolence (secondary outcome 2) · participants with acute pancreatitis pain

Opioids showed no clear difference in sedation and somnolence (secondary outcome 2) compared with no opioids (low certainty).

1 finding from 1 review

Opioids vs no opioids

Death from any cause (secondary outcome 3) · participants with acute pancreatitis pain

It is very uncertain whether opioids changes death from any cause (secondary outcome 3) compared with no opioids (very low certainty).

1 finding from 1 review