Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,252 questions · 2,353 findings · 210 reviews · Neonatal

No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Rescue high‐frequency jet ventilation vs conventional ventilation

Overall mortality · preterm infants with severe pulmonary dysfunction

Rescue high‐frequency jet ventilation showed no clear difference in overall mortality compared with conventional ventilation (low certainty).

1 finding from 1 review

Rescue high‐frequency jet ventilation vs conventional ventilation

Mortality before cross‐over · preterm infants with severe pulmonary dysfunction

Rescue high‐frequency jet ventilation probably leads to lower mortality before cross‐over compared with conventional ventilation (moderate certainty).

1 finding from 1 review

Rescue high‐frequency jet ventilation vs conventional ventilation

Chronic lung disease · preterm infants with severe pulmonary dysfunction

Rescue high‐frequency jet ventilation showed no clear difference in chronic lung disease at 28 days of birth (CLD 28 days) compared with conventional ventilation (low certainty).

2 findings from 1 review

Rescue high‐frequency jet ventilation vs conventional ventilation

Pulmonary air leak (new) · preterm infants with severe pulmonary dysfunction

Rescue high‐frequency jet ventilation showed no clear difference in pulmonary air leak (new) compared with conventional ventilation (low certainty).

1 finding from 1 review

Rescue high‐frequency jet ventilation vs conventional ventilation

Severe intraventricular haemorrhage · preterm infants with severe pulmonary dysfunction

Rescue high‐frequency jet ventilation showed no clear difference in severe intraventricular haemorrhage (grades 3 and 4) compared with conventional ventilation (low certainty).

1 finding from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Apnoea/bradycardia occurring 12‐24 hours following completion of operation · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) showed no clear difference in apnoea/bradycardia occurring 12‐24 hours following completion of… compared with general anaesthesia (moderate certainty).

1 finding from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Any oxygen desaturation occurring 12‐24 hours following completion of the operation · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) showed no clear difference in any oxygen desaturation occurring 12‐24 hours following completion… compared with general anaesthesia (moderate certainty).

1 finding from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Use of post‐operative respiratory support · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) showed no clear difference in use of post‐operative respiratory support compared with general anaesthesia (low certainty).

1 finding from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Post‐operative apnoea with preoperative sedatives excluded · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) probably leads to lower post‐operative apnoea with preoperative sedatives excluded compared with general anaesthesia (moderate certainty).

1 finding from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Anaesthetic agent failure · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) may leads to higher anaesthetic agent failure compared with general anaesthesia (low certainty).

1 finding from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Anaesthetic placement failure · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) showed no clear difference in anaesthetic placement failure compared with general anaesthesia (low certainty).

1 finding from 1 review

Intervention not reported

Mortality during hospitalisation number of infants with event · patients with preventing morbidity and mortality in neonates

The intervention showed no clear difference in mortality during hospitalisation number of infants with event (moderate certainty).

1 finding from 1 review

Intervention not reported

Risk of proven septicaemia per infant number of infants with the event · patients with preventing morbidity and mortality in neonates

The intervention showed no clear difference in risk of proven septicaemia per infant number of infants with the event (moderate certainty).

1 finding from 1 review

Intervention not reported

Suspected septicaemia number of infants with the event · patients with preventing morbidity and mortality in neonates

The intervention showed no clear difference in suspected septicaemia number of infants with the event (low certainty).

1 finding from 1 review

Intervention not reported

Localised thrombi number of infants with event · patients with preventing morbidity and mortality in neonates

The intervention showed no clear difference in localised thrombi number of infants with event (low certainty).

1 finding from 1 review

Intervention not reported

Proven necrotising enterocolitis number of infants with the event · patients with preventing morbidity and mortality in neonates

The intervention showed no clear difference in proven necrotising enterocolitis number of infants with the event (low certainty).

1 finding from 1 review