Findings

What do systematic reviews say?

2,252 questions · 2,353 findings · 210 reviews · Neonatal

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No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Co‐bedding vs separate care

Parental satisfaction · patients with promoting growth and neurodevelopment in stable preterm twins

1 finding from 1 review

Co‐bedding in neonatal nursery for promoting growth and neurodevelopment in stable preterm twins 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Moderate

Co‐bedding vs separate care

Pain (PIPP) · patients with promoting growth and neurodevelopment in stable preterm twins

1 finding from 1 review

Co‐bedding in neonatal nursery for promoting growth and neurodevelopment in stable preterm twins 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 224 participants
Low

Higher vs lower PUFA

All allergic disease ‐ Infancy (incidence) · infants

It is very uncertain whether higher changes all allergic disease ‐ infant incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.96 [0.73, 1.26]
1 study · 323 participants
Very low

Higher vs lower PUFA

All allergic disease ‐ childhood prevalence · infants

It is very uncertain whether higher changes all allergic disease ‐ childhood prevalence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.98 [0.81, 1.19]
2 studies · 633 participants
Very low

Higher vs lower PUFA

Asthma ‐ childhood prevalence · infants

It is very uncertain whether higher changes asthma ‐ childhood prevalence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 1.12 [0.82, 1.53]
2 studies · 635 participants
Very low

Higher vs lower PUFA

Dermatitis/eczema ‐ childhood prevalence · infants

It is very uncertain whether higher changes dermatitis/eczema ‐ childhood prevalence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.81 [0.59, 1.09]
2 studies · 635 participants
Very low

Higher vs lower PUFA

Allergic rhinitis ‐ childhood prevalence · infants

It is very uncertain whether higher changes allergic rhinitis ‐ childhood prevalence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 1.02 [0.83, 1.25]
2 studies · 635 participants
Very low

Higher vs lower PUFA

Food allergy ‐ childhood prevalence · infants

It is very uncertain whether higher changes food allergy ‐ childhood prevalence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.27 [0.06, 1.19]
1 study · 119 participants
Very low

Higher vs lower PUFA

Asthma ‐ Infancy (incidence) · infants

Higher showed no clear difference in asthma ‐ infant incidence compared with lower PUFA intake (low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 1.04 [0.8, 1.35]
3 studies · 1162 participants
Low

Higher vs lower PUFA

Eczema ‐ Infancy (incidence) · infants

It is very uncertain whether higher changes dermatitis/eczema ‐ infant incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.93 [0.82, 1.06]
7 studies · 1906 participants
Very low

Higher vs lower PUFA

Allergic rhinitis ‐ infant incidence · infants

It is very uncertain whether higher changes allergic rhinitis ‐ infant incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.47 [0.23, 0.96]
2 studies · 594 participants
Very low

Higher vs lower PUFA

Food allergy ‐ Infancy (incidence) · infants

It is very uncertain whether higher changes food allergy ‐ infant incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.81 [0.56, 1.19]
3 studies · 915 participants
Very low

Higher vs lower PUFA

All allergic disease ‐ childhood (incidence) · infants

It is very uncertain whether higher changes all allergic disease ‐ childhood incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.69 [0.47, 1.02]
2 studies · 154 participants
Very low

Higher vs lower PUFA

Asthma ‐ childhood (incidence) · infants

It is very uncertain whether higher changes asthma ‐ childhood incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.45 [0.2, 1.02]
1 study · 89 participants
Very low

Higher vs lower PUFA

Eczema ‐ childhood (incidence) · infants

It is very uncertain whether higher changes dermatitis/eczema ‐ childhood incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.65 [0.34, 1.24]
2 studies · 154 participants
Very low

Higher vs lower PUFA

Food allergy ‐ childhood (incidence) · infants

It is very uncertain whether higher changes food allergy ‐ childhood incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 2.27 [0.25, 20.68]
1 study · 65 participants
Very low

Intervention not reported

Death from any cause prior to hospital discharge · Neonates with PPHN

The intervention showed no clear difference in death from any cause prior to hospital discharge (low certainty).

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
RR 0.2 [0.02, 1.77]
37 participants
Low

Intervention not reported

Percentage of infants that showed improvement in OI by at least 20% by the end of therapy · Neonates with PPHN

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
39 participants
Low

Intervention not reported

Adverse neurological outcomes at six months of age · Neonates with PPHN

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
37 participants
Low

Intervention not reported

Cerebral Palsy · Neonates with PPHN

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
37 participants
Low