What do systematic reviews say?

Prone vs supine

• Infant position in neonates receiving mechanical ventilation 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 116 participants
  Moderate

Prone vs supine

• Infant position in neonates receiving mechanical ventilation 2016 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 308 participants
  Very low

Prone vs supine

• Infant position in neonates receiving mechanical ventilation 2016 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 92 participants
  Moderate

Postdischarge formula vs standard term formula

• Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 523 participants
  Moderate
• Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 576 participants
  Moderate

Preterm formula vs standard term formula

• Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 130 participants
  Moderate
• Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 160 participants
  Moderate

Preterm formula vs standard term formula

• Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 130 participants
  Moderate
• Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 160 participants
  Moderate

Preterm formula vs standard term formula

• Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 143 participants
  High

Postdischarge formula vs standard term formula

• Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 523 participants
  Moderate
• Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 576 participants
  Moderate

Postdischarge formula vs standard term formula

• Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 523 participants
  Moderate
• Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 576 participants
  Moderate

Postdischarge formula vs standard term formula

• Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 184 participants
  High

Preterm formula vs standard term formula

• Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 130 participants
  Moderate
• Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 273 participants
  Moderate

Intervention not reported

It is very uncertain whether the intervention changes clearance of proven sepsis (very low certainty).

• One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in… 2016 · Cochrane Headline outcomes only
  RR 1 [0.84, 1.19]
  3 studies · 37 participants
  Very low

Intervention not reported

The intervention probably leads to lower failure to achieve peak levels of at least 5 microgram/ml (measured… (moderate certainty).

• One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in… 2016 · Cochrane Headline outcomes only
  RR 0.22 [0.11, 0.47]
  9 studies · 422 participants
  Moderate

Intervention not reported

• One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 348 participants
  GRADE not reported

Intervention not reported

It is very uncertain whether the intervention changes ototoxicity (End of study period or before discharge) (very low certainty).

• One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in… 2016 · Cochrane Headline outcomes only
  RR 1.69 [0.18, 16.25]
  5 studies · 214 participants
  Very low

Intervention not reported

The intervention probably leads to lower failure to achieve trough levels of ≤2 microgram/ml ( (moderate certainty).

• One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in… 2016 · Cochrane Headline outcomes only
  RR 0.38 [0.27, 0.55]
  11 studies · 503 participants
  Moderate

Intervention not reported

• Cup feeding versus other forms of supplemental enteral feeding for newborn infants unable to fully breastfeed 2016 · Cochrane Headline outcomes only
  no estimate extracted
  522 participants
  Low

Intervention not reported

• Cup feeding versus other forms of supplemental enteral feeding for newborn infants unable to fully breastfeed 2016 · Cochrane Headline outcomes only
  no estimate extracted
  957 participants
  Low

Intervention not reported

It is very uncertain whether the intervention changes not breastfeeding at six months (very low certainty).

• Cup feeding versus other forms of supplemental enteral feeding for newborn infants unable to fully breastfeed 2016 · Cochrane Headline outcomes only
  RR 0.83 [0.72, 0.95]
  803 participants
  Very low

Intervention not reported

The intervention may leads to lower not fully breastfeeding at hospital discharge (low certainty).

• Cup feeding versus other forms of supplemental enteral feeding for newborn infants unable to fully breastfeed 2016 · Cochrane Headline outcomes only
  RR 0.61 [0.52, 0.71]
  893 participants
  Low