Findings

What do systematic reviews say?

5 questions · 5 findings · 5 reviews · Heart

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 20%Low 3 · 60%Moderate 1 · 20%High 0 · 0%

Systematic screening vs no/opportunistic screening

Stroke · general population including those at moderate to high risk of CVD, mean age between 30 and 75

Systematic screening showed no clear difference in stroke (total) compared with no/opportunistic screening (low certainty).

1 finding from 1 review

Systematic versus opportunistic risk assessment for the primary prevention of cardiovascular disease 2016 · Cochrane Headline outcomes only
RR 0.99 [0.9, 1.1]
2 studies · 79631 participants
Low

Colchicine vs any control treatment

Stroke · any patient population and people with high cardiovascular risk

Colchicine showed no clear difference in stroke (total) compared with any control treatment (low certainty).

1 finding from 1 review

Colchicine for prevention of cardiovascular events 2016 · Cochrane Headline outcomes only
OR 0.38 [0.09, 1.7]
3 studies · 874 participants
Low

Vitamin C vs placebo

Stroke · middle‐aged US male physicians

Vitamin C supplementation showed no clear difference in total stroke (fatal and non‐fatal) Physicians compared with placebo (low certainty).

1 finding from 1 review

Vitamin C supplementation for the primary prevention of cardiovascular disease 2017 · Cochrane Headline outcomes only
HR 0.89 [0.74, 1.07]
1 study · 14641 participants
Low

Statins vs Control at 4 months (3 ‐ 6 months)

Combined outcome of non‐fatal myocardial infarction, non‐fatal stroke, and total number of deaths · patients with acute coronary syndrome

Statins showed no clear difference in combined outcome of non‐fatal myocardial infarction, non‐fatal… compared with control at 4 months (3 to 6 months) (moderate certainty).

1 finding from 1 review

Statins for acute coronary syndrome 2014 · Cochrane Headline outcomes only
RR 0.93 [0.81, 1.06]
11 studies · 9625 participants
Moderate

Mediterranean dietary intervention vs another dietary intervention

Total cardiac endpoints (all‐cause and cardiac deaths, myocardial infarction, hospital admissions for heart failure, unstable angina or stroke, unadjusted) · adults with established cardiovascular disease

It is very uncertain whether mediterranean dietary intervention changes total cardiac endpoints (all‐cause and cardiac deaths, myocardial… compared with another dietary intervention (very low certainty).

1 finding from 1 review

Mediterranean‐style diet for the primary and secondary prevention of cardiovascular disease 2019 · Cochrane Headline outcomes only
RR 0.98 [0.4, 2.41]
1 study · 101 participants
Very low