Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,337 questions · 1,354 findings · 566 reviews

No studies found 307 · 22.7%GRADE not reported 81 · 6%Very low 424 · 31.3%Low 310 · 22.9%Moderate 189 · 14%High 43 · 3.2%

Leflunomide vs methotrexate

Serious adverse events* · adults with renal vasculitis for maintenance therapy

Leflunomide showed no clear difference in serious adverse events* compared with methotrexate (low certainty).

1 finding from 1 review

Exercise vs no exercise at longest available follow‐up

Serious adverse events ( · adult patients with an implantable cardioverter defibrillator

It is very uncertain whether exercise changes serious adverse events ( compared with no exercise at longest available follow‐up (very low certainty).

1 finding from 1 review