Findings

What do systematic reviews say?

9 questions · 12 findings · 5 reviews · Musculoskeletal

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No studies found 1 · 8.3%GRADE not reported 0 · 0%Very low 1 · 8.3%Low 7 · 58.3%Moderate 3 · 25%High 0 · 0%

NSAIDs vs glucocorticoids

HRQOL ‐ not measured · acute gout

The review found no eligible studies for this question.

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Lateral wedge insole vs neutral insole

Health‐related quality of life (HRQoL) · patients with varus medial osteoarthritis of the knee

1 finding from 1 review

Braces and orthoses for treating osteoarthritis of the knee 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 179 participants
Moderate

Intervention not reported

Health‐related quality of life (HRQoL) Scale from 0 to 1.0 · patients with varus medial osteoarthritis of the knee

1 finding from 1 review

Braces and orthoses for treating osteoarthritis of the knee 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 179 participants
Moderate

Prefabricated foot orthoses vs shoes

QoL · children with symptomatic flat feet

1 finding from 1 review

Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Custom foot orthoses vs shoes

QoL · children with juvenile idiopathic arthritis and flat feet

2 findings from 1 review

Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low
Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Prefabricated foot orthoses vs shoes

QoL · children with juvenile idiopathic arthritis and flat feet

2 findings from 1 review

Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low
Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Custom foot orthoses vs prefabricated foot orthoses

QoL · children with juvenile idiopathic arthritis and flat feet

2 findings from 1 review

Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low
Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Quality of life (at study completion) EuroQol (VAS) from 0 to 200 mm; higher score means better function · People with hip or knee osteoarthritis

1 finding from 1 review

High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 214 participants
Very low

Antidepressants vs placebo

Quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0 indicates perfect health) between 0 and 14 weeks · predominantly knee osteoarthritis

Antidepressant probably leads to higher quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0… compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants for hip and knee osteoarthritis 2022 · Cochrane Headline outcomes only
MD 0.04 [0.01, 0.07]
3 studies · 815 participants
Moderate