Findings

What do systematic reviews say?

3,241 questions · 3,336 findings · 1,340 reviews

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No studies found 1,581 · 47.4%GRADE not reported 352 · 10.6%Very low 512 · 15.3%Low 509 · 15.3%Moderate 316 · 9.5%High 66 · 2%

Summary of findings for the main comparison: comprehensive care programmes vs usual care

Child health, functioning, and quality of life Pediatric Quality of Life Inventory (PedsQL) · children with medical complexity

1 finding from 1 review

Comprehensive care programmes for children with medical complexity 2024 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 701 participants
Low

Anti‐IL‐4Rα mAb (dupilumab) vs placebo (on top of topical steroids)

Disease‐specific quality of life · patients with severe chronic rhinosinusitis with nasal polyps

1 finding from 1 review

Biologics for chronic rhinosinusitis 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 784 participants
High

Anti‐IgE mAb (omalizumab) vs placebo (on top of topical steroids)

Disease‐specific quality of life · patients with chronic rhinosinusitis with nasal polyps

1 finding from 1 review

Biologics for chronic rhinosinusitis 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 265 participants
Moderate

Anti‐IL‐5 mAb (mepolizumab) vs placebo (on top of topical steroids)

Disease‐specific quality of life · patients with severe chronic rhinosinusitis with nasal polyps

1 finding from 1 review

Biologics for chronic rhinosinusitis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 105 participants
Low

Benralizumab 100 mg vs placebo

Change in SGRQ total score · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1433 participants
High

Alginate (two stage-two step final/wash impression) vs Silicone elastomer (two stage-two step)

Oral health-related quality of life · Completely edentulous people

Alginate (two stage-two step final/wash impression) may leads to higher participant-reported oral health-related quality of life… compared with silicone elastomer (two stage-two step) (low certainty).

1 finding from 1 review

Final‐impression techniques and materials for making complete and removable partial dentures 2018 · Cochrane All outcomes
2 weeks
MD 7.20 [2.71, 11.69]
1 study · 144 participants
Low

Diaphragmatic breathing vs no breathing exercises

Health‐related quality of life Change in total score of St George Respiratory Questionnaire · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Breathing exercises for chronic obstructive pulmonary disease 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Moderate

Custom foot orthoses vs shoes

QoL · children with juvenile idiopathic arthritis and flat feet

2 findings from 1 review

Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low
Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Prefabricated foot orthoses vs shoes

QoL · children with juvenile idiopathic arthritis and flat feet

2 findings from 1 review

Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low
Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Custom foot orthoses vs prefabricated foot orthoses

QoL · children with juvenile idiopathic arthritis and flat feet

2 findings from 1 review

Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low
Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Summary of findings: Molecular‐targeted therapy plus chemotherapy vs chemotherapy alone

Health status and quality of life · people with advanced gastric cancer

1 finding from 1 review

Molecular‐targeted first‐line therapy for advanced gastric cancer 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 53 participants
Very low

Intervention not reported

Quality of life Self‐report questionnaire. Scale from 0‐100 (100 is maximum quality of life) · patients with knee OA

1 finding from 1 review

Exercise for osteoarthritis of the knee 2015 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 1073 participants
High

Collaborative care vs usual care

Quality of life/Mental health outcome · severe mental illness

1 finding from 1 review

Collaborative care approaches for people with severe mental illness 2024 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 227 participants
Very low

Summary of findings ‐ dual therapy: lumacaftor plus ivacaftor (once daily) vs placebo

Quality of life ‐ (EuroQol) EQ‐5D‐3L Index Score (total score): absolute change from baseline · adults and children with cystic fibrosis

1 finding from 1 review

Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1061 participants
Moderate

Summary of findings table ‐ Antipsychotic dose reduction vs dose continuation

Quality of life ‐ mean change/endpoint all available scales (combined scales and time points) · patients with schizophrenia

1 finding from 1 review

Antipsychotic dose reduction compared to dose continuation for people with schizophrenia 2022 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 719 participants
Moderate

Group 1 Pulmonary arterial hypertension ‐ PDE5i vs placebo, on combination therapy

Physical functioning component of health‐related quality of life, measured using various scales · pulmonary arterial hypertension

1 finding from 1 review

Phosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 267 participants
Moderate

Laparoscopic vs open appendectomy

Quality of life Scale used: 1) Gastro‐intestinal Quality of Life Index 2) SF‐36 questionnaire · patients with suspected appendicitis

1 finding from 1 review

Laparoscopic versus open surgery for suspected appendicitis 2018 · Cochrane Headline outcomes only
2
2009 participants
Low

Intervention not reported

Quality of life on a 0 to 100 scale. Various quality of life scales. (higher score is better)

1 finding from 1 review

Aquatic exercise for the treatment of knee and hip osteoarthritis 2016 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 1027 participants
Moderate

Intervention not reported

Quality of life (Asthma Quality of Life Questionnaire, with 32 items, 0 to 7 points per item) · People with asthma (mostly mild or moderate)

1 finding from 1 review

Yoga for asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 375 participants
Moderate

DHEA vs placebo or control

QoL · Women in the peri‐ or postmenopausal phase

1 finding from 1 review

Dehydroepiandrosterone for women in the peri‐ or postmenopausal phase 2015 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 287 participants
Moderate