What do systematic reviews say?

Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs land‐based exercise therapy

• Adjunctive therapies in addition to land‐based exercise therapy for osteoarthritis of the hip or knee 2022 · Cochrane Headline outcomes only
  no estimate extracted
  41 studies · 3323 participants
  Very low

Trapeziectomy with ligament reconstruction and tendon interposition (T and LRTI) vs trapeziectomy and ligament reconstruction (T and LR)

Trapeziectomy with ligament reconstruction and tendon interposition… showed no clear difference in physical function Buck‐Gramcko score: Number with good‐excellent… compared with trapeziectomy and ligament reconstruction (T and LR) (low certainty).

• Surgery for thumb (trapeziometacarpal joint) osteoarthritis 2015 · Cochrane Headline outcomes only
  RR 0.82 [0.63, 1.06]
  1 study · 31 participants
  Low

Antidepressants vs placebo

Antidepressant showed no clear difference in mean change in physical function from baseline (0–100 WOMAC Total… compared with placebo (high certainty).

• Antidepressants for hip and knee osteoarthritis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 1909 participants
  High

Intervention not reported

• Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 45 participants
  Low