Findings

What do systematic reviews say?

7 questions · 7 findings · 5 reviews

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 1 · 14.3%High 3 · 42.9%

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Patients' quality of life · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Pre-radiotherapy extraction of diseased molar teeth vs Conservative treatment (restoration of the teeth and leaving them in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Patients' quality of life · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Tiotropium vs placebo

Number of patients with a clinically significant worsening (≥ 4 units) in quality of life (SGRQ) · people with COPD who have smoked for ≥ 10 pack‐years

Tiotropium leads to lower number of patients with a clinically significant worsening (≥ 4… compared with placebo (high certainty).

1 finding from 1 review

Tiotropium versus placebo for chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
OR 0.65 [0.59, 0.72]
9 studies · 11672 participants
High

Aclidinium bromide vs placebo

Quality of life: number of participants with clinically significant improvement (≥ 4 units) in SGRQ total score · patients with stable chronic obstructive pulmonary disease

Aclidinium bromide leads to higher quality of life Number of patients who achieved at least 4 units… compared with placebo (high certainty).

1 finding from 1 review

Aclidinium bromide for stable chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
OR 1.49 [1.31, 1.7]
7 studies · 4420 participants
High

Tiotropium vs placebo

Quality of life: number of participants with clinically significant improvement (≥ 4 units) in SGRQ total score · people with COPD who have smoked for ≥ 10 pack‐years

Tiotropium leads to higher number of patients with a clinically significant improvement (≥ 4… compared with placebo (high certainty).

1 finding from 1 review

Tiotropium versus placebo for chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
OR 1.52 [1.38, 1.68]
9 studies · 11672 participants
High

Rivastigmine vs placebo

Quality of life of patients or carers (measured using NPI‐D carer distress scale (change from baseline at 24 weeks) · Apathy in people with mild‐to‐moderate Alzheimer's disease

1 finding from 1 review

Rivastigmine for Alzheimer's disease 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 529 participants
Moderate

Ruxolitinib vs placebo

Health‐related quality of life Patients that achieved a reduction of 50% or more in the total MF Symptom Assessment Form · Patients with treating MF

Ruxolitinib may leads to higher health‐related quality of life Patients that achieved a reduction of… compared with placebo (low certainty).

1 finding from 1 review

Janus kinase‐1 and Janus kinase‐2 inhibitors for treating myelofibrosis 2015 · Cochrane Headline outcomes only
RR 8.82 [4.4, 17.69]
1 study · 309 participants
Low