Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 10 findings · 3 reviews · Musculoskeletal

No studies found 2 · 20%GRADE not reported 1 · 10%Very low 4 · 40%Low 3 · 30%Moderate 0 · 0%High 0 · 0%

Celecoxib vs tNSAIDs

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing any serious adverse events compared with tNSAIDs (very low certainty).

1 finding from 1 review

Celecoxib vs placebo

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing any serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Tramadol vs paracetamol

Number of participants experiencing any serious adverse events · patients with osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol vs NSAIDs

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether tramadol alone changes number of participants experiencing any serious adverse events compared with NSAIDs (very low certainty).

1 finding from 1 review

Tramadol vs other opioids

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether tramadol alone changes number of participants experiencing any serious adverse events compared with other opioids (very low certainty).

1 finding from 1 review

Tramadol vs placebo

Number of participants experiencing any serious adverse events · Patients with osteoarthritis of the knee or hip

Tramadol alone may leads to higher number of participants experiencing any serious adverse events compared with placebo (low certainty).

1 finding from 1 review