Adalimumab vs placebo
Adalimumab leads to lower failure to maintain clinical remission compared with placebo (high certainty).
- RR 0.7 [0.64, 0.77]3 studies · 683 participantsHigh
- RR 0.66 [0.52, 0.83]2 studies · 554 participantsModerate
Adalimumab leads to lower failure to maintain clinical remission compared with placebo (high certainty).
The review found no eligible studies for this question.
Antibiotic showed no clear difference in failure to maintain clinical remission compared with placebo (low certainty).
The review found no eligible studies for this question.
Ustekinumab showed no clear difference in failure to maintain clinical remission compared with placebo (moderate certainty).
Briakinumab showed no clear difference in failure to maintain clinical remission compared with placebo (low certainty).
Oral 5‐aminosalicylic acid leads to lower failure to maintain clinical or endoscopic remission compared with placebo (high certainty).
Once‐daily dosing showed no clear difference in failure to maintain clinical or endoscopic remission compared with conventional dosing (high certainty).
Oral 5‐aminosalicylic acid showed no clear difference in failure to maintain clinical or endoscopic remission compared with comparator 5‐aminosalicylic acid formulation (low certainty).
Oral 5‐aminosalicylic acid leads to higher failure to maintain clinical or endoscopic remission compared with sulfasalazine (high certainty).
It is very uncertain whether antibiotics changes failure to maintain clinical remission at end of study compared with 5‐ASA (very low certainty).
Certolizumab pegol probably leads to lower failure to maintain clinical remission at week 26(1 RCT, 428… compared with placebo (moderate certainty).