Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 14 findings · 6 reviews · Gut

No studies found 2 · 14.3%GRADE not reported 0 · 0%Very low 1 · 7.1%Low 3 · 21.4%Moderate 4 · 28.6%High 4 · 28.6%

Adalimumab vs placebo

Failure to maintain remission · Participants with Crohn's disease in remission

Adalimumab leads to lower failure to maintain clinical remission compared with placebo (high certainty).

2 findings from 1 review

Ustekinumab vs placebo

Failure to maintain remission · people with moderate to severe Crohn's disease in remission

Ustekinumab showed no clear difference in failure to maintain clinical remission compared with placebo (moderate certainty).

2 findings from 1 review

Oral 5‐aminosalicylic acid vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Failure to maintain clinical or endoscopic remission · Patients with quiescent ulcerative colitis

Oral 5‐aminosalicylic acid showed no clear difference in failure to maintain clinical or endoscopic remission compared with comparator 5‐aminosalicylic acid formulation (low certainty).

1 finding from 1 review

Antibiotics vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Failure to maintain clinical remission at end of study · Patients with quiescent ulcerative colitis

It is very uncertain whether antibiotics changes failure to maintain clinical remission at end of study compared with 5‐ASA (very low certainty).

1 finding from 1 review

Certolizumab pegol vs placebo

Failure to maintain clinical remission at end of study · people with Crohn's disease who responded to CZP remission‐induction treatment

Certolizumab pegol probably leads to lower failure to maintain clinical remission at week 26(1 RCT, 428… compared with placebo (moderate certainty).

1 finding from 1 review